Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species
Abstract Background Lipids are important for the cell and organism life since they are major components of membranes, energy reserves and are also signal molecules. The main organs for the energy synthesis and storage are the liver and adipose tissue, both in humans and in more distant species such...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Genomics |
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| Online Access: | http://link.springer.com/article/10.1186/s12864-019-6093-3 |
| _version_ | 1828837530293764096 |
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| author | Kevin Muret Colette Désert Laetitia Lagoutte Morgane Boutin Florence Gondret Tatiana Zerjal Sandrine Lagarrigue |
| author_facet | Kevin Muret Colette Désert Laetitia Lagoutte Morgane Boutin Florence Gondret Tatiana Zerjal Sandrine Lagarrigue |
| author_sort | Kevin Muret |
| collection | DOAJ |
| description | Abstract Background Lipids are important for the cell and organism life since they are major components of membranes, energy reserves and are also signal molecules. The main organs for the energy synthesis and storage are the liver and adipose tissue, both in humans and in more distant species such as chicken. Long noncoding RNAs (lncRNAs) are known to be involved in many biological processes including lipid metabolism. Results In this context, this paper provides the most exhaustive list of lncRNAs involved in lipid metabolism with 60 genes identified after an in-depth analysis of the bibliography, while all “review” type articles list a total of 27 genes. These 60 lncRNAs are mainly described in human or mice and only a few of them have a precise described mode-of-action. Because these genes are still named in a non-standard way making such a study tedious, we propose a standard name for this list according to the rules dictated by the HUGO consortium. Moreover, we identified about 10% of lncRNAs which are conserved between mammals and chicken and 2% between mammals and fishes. Finally, we demonstrated that two lncRNA were wrongly considered as lncRNAs in the literature since they are 3′ extensions of the closest coding gene. Conclusions Such a lncRNAs catalogue can participate to the understanding of the lipid metabolism regulators; it can be useful to better understand the genetic regulation of some human diseases (obesity, hepatic steatosis) or traits of economic interest in livestock species (meat quality, carcass composition). We have no doubt that this first set will be rapidly enriched in coming years. |
| first_indexed | 2024-12-12T18:42:53Z |
| format | Article |
| id | doaj.art-7ace0a3f15ca469ebc759aa5c1dcb749 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-12T18:42:53Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-7ace0a3f15ca469ebc759aa5c1dcb7492022-12-22T00:15:35ZengBMCBMC Genomics1471-21642019-11-0120111810.1186/s12864-019-6093-3Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across speciesKevin Muret0Colette Désert1Laetitia Lagoutte2Morgane Boutin3Florence Gondret4Tatiana Zerjal5Sandrine Lagarrigue6PEGASE, INRA, AGROCAMPUS OUESTPEGASE, INRA, AGROCAMPUS OUESTPEGASE, INRA, AGROCAMPUS OUESTPEGASE, INRA, AGROCAMPUS OUESTPEGASE, INRA, AGROCAMPUS OUESTGABI INRA, AgroParisTech, Université Paris-SaclayPEGASE, INRA, AGROCAMPUS OUESTAbstract Background Lipids are important for the cell and organism life since they are major components of membranes, energy reserves and are also signal molecules. The main organs for the energy synthesis and storage are the liver and adipose tissue, both in humans and in more distant species such as chicken. Long noncoding RNAs (lncRNAs) are known to be involved in many biological processes including lipid metabolism. Results In this context, this paper provides the most exhaustive list of lncRNAs involved in lipid metabolism with 60 genes identified after an in-depth analysis of the bibliography, while all “review” type articles list a total of 27 genes. These 60 lncRNAs are mainly described in human or mice and only a few of them have a precise described mode-of-action. Because these genes are still named in a non-standard way making such a study tedious, we propose a standard name for this list according to the rules dictated by the HUGO consortium. Moreover, we identified about 10% of lncRNAs which are conserved between mammals and chicken and 2% between mammals and fishes. Finally, we demonstrated that two lncRNA were wrongly considered as lncRNAs in the literature since they are 3′ extensions of the closest coding gene. Conclusions Such a lncRNAs catalogue can participate to the understanding of the lipid metabolism regulators; it can be useful to better understand the genetic regulation of some human diseases (obesity, hepatic steatosis) or traits of economic interest in livestock species (meat quality, carcass composition). We have no doubt that this first set will be rapidly enriched in coming years.http://link.springer.com/article/10.1186/s12864-019-6093-3lncRNALipid metabolismLiverEvolutionSynteny |
| spellingShingle | Kevin Muret Colette Désert Laetitia Lagoutte Morgane Boutin Florence Gondret Tatiana Zerjal Sandrine Lagarrigue Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species BMC Genomics lncRNA Lipid metabolism Liver Evolution Synteny |
| title | Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species |
| title_full | Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species |
| title_fullStr | Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species |
| title_full_unstemmed | Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species |
| title_short | Long noncoding RNAs in lipid metabolism: literature review and conservation analysis across species |
| title_sort | long noncoding rnas in lipid metabolism literature review and conservation analysis across species |
| topic | lncRNA Lipid metabolism Liver Evolution Synteny |
| url | http://link.springer.com/article/10.1186/s12864-019-6093-3 |
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