Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

Epistatic interaction between PKD2 and ABCG2 influences the pathogenesis of hyperuricemia and gout

Abstract Background Genetic background affects serum urate concentration and gout risk, especially regarding these variants in the urate-transporter gene ABCG2. However, the role of epistasis between PKD2 and ABCG2 on the pathogenesis of gout is poorly understood. Here we assess this epistatic inter...

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Bibliographic Details
Main Authors: Zheng Dong, Jingru Zhou, Shuai Jiang, Yuan Li, Dongbao Zhao, Chengde Yang, Yanyun Ma, Hongjun He, Hengdong Ji, Li Jin, Hejian Zou, Jiucun Wang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Hereditas
Subjects:
Epistasis
Serum urate
Body mass index (BMI)
Gene transcript
Gender
Enhancer
Online Access:https://doi.org/10.1186/s41065-020-0116-6

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