The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis
Functional bladder disorders including overactive bladder and interstitial cystitis may induce problems in many other parts of our body such as brain and gut. In fact, diagnosis is often less accurate owing to their complex symptoms. To have correct diagnosis of these diseases, we need to understand...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Continence Society
2023-03-01
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| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://einj.org/upload/pdf/inj-2346036-018.pdf |
| _version_ | 1797852252886532096 |
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| author | Jiwon Jung Aram Kim Seung-Hoon Yang |
| author_facet | Jiwon Jung Aram Kim Seung-Hoon Yang |
| author_sort | Jiwon Jung |
| collection | DOAJ |
| description | Functional bladder disorders including overactive bladder and interstitial cystitis may induce problems in many other parts of our body such as brain and gut. In fact, diagnosis is often less accurate owing to their complex symptoms. To have correct diagnosis of these diseases, we need to understand the pathophysiology behind overlapped clinical presentation. First, we focused on reviewing literatures that have reported the link between bladder and brain, as the patients with bladder disorders frequently accompanied mood disorders such as depression and anxiety. Second, we reviewed literatures that have described the relationship between bladder and gut. There exist many evidences of patients who suffered from both bladder and intestinal diseases, such as irritable bowel syndrome and inflammatory bowel disease, at the same time. Furthermore, the interaction between brain and gut, well-known as brain-gut axis, might be a key factor that could change the activity of bladder and vice versa. For example, the affective disorders could alter the activity of efferent nerves or autonomic nervous system that modulate the gut itself and its microbiota, which might cause the destruction of homeostasis in bladder eventually. In this way, the communication between bladder and brain-gut axis might affect permeability, inflammation, as well as infectious etiology and dysbiosis in bladder diseases. In this review, we aimed to find an innovative insight of the pathophysiology in the functional bladder disorders, and we could provide a new understanding of the overlapped clinical presentation by elucidating the pathophysiology of functional bladder disorders. |
| first_indexed | 2024-04-09T19:30:03Z |
| format | Article |
| id | doaj.art-7ad1c95e16294ba08e5860a395adda39 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-04-09T19:30:03Z |
| publishDate | 2023-03-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-7ad1c95e16294ba08e5860a395adda392023-04-05T00:44:39ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312023-03-01271152210.5213/inj.2346036.0181041The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut AxisJiwon Jung0Aram Kim1Seung-Hoon Yang2 Department of Biomedical Engineering, College of Life Science and Biotechnology, Dongguk University, Seoul, Korea Department of Urology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea Department of Biomedical Engineering, College of Life Science and Biotechnology, Dongguk University, Seoul, KoreaFunctional bladder disorders including overactive bladder and interstitial cystitis may induce problems in many other parts of our body such as brain and gut. In fact, diagnosis is often less accurate owing to their complex symptoms. To have correct diagnosis of these diseases, we need to understand the pathophysiology behind overlapped clinical presentation. First, we focused on reviewing literatures that have reported the link between bladder and brain, as the patients with bladder disorders frequently accompanied mood disorders such as depression and anxiety. Second, we reviewed literatures that have described the relationship between bladder and gut. There exist many evidences of patients who suffered from both bladder and intestinal diseases, such as irritable bowel syndrome and inflammatory bowel disease, at the same time. Furthermore, the interaction between brain and gut, well-known as brain-gut axis, might be a key factor that could change the activity of bladder and vice versa. For example, the affective disorders could alter the activity of efferent nerves or autonomic nervous system that modulate the gut itself and its microbiota, which might cause the destruction of homeostasis in bladder eventually. In this way, the communication between bladder and brain-gut axis might affect permeability, inflammation, as well as infectious etiology and dysbiosis in bladder diseases. In this review, we aimed to find an innovative insight of the pathophysiology in the functional bladder disorders, and we could provide a new understanding of the overlapped clinical presentation by elucidating the pathophysiology of functional bladder disorders.http://einj.org/upload/pdf/inj-2346036-018.pdfurinary bladder diseasesmood disordersintestinal diseasesbrain-gut axis |
| spellingShingle | Jiwon Jung Aram Kim Seung-Hoon Yang The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis International Neurourology Journal urinary bladder diseases mood disorders intestinal diseases brain-gut axis |
| title | The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis |
| title_full | The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis |
| title_fullStr | The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis |
| title_full_unstemmed | The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis |
| title_short | The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis |
| title_sort | innovative approach in functional bladder disorders the communication between bladder and brain gut axis |
| topic | urinary bladder diseases mood disorders intestinal diseases brain-gut axis |
| url | http://einj.org/upload/pdf/inj-2346036-018.pdf |
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