Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus
Diabetic microangiopathy is a typical and severe problem in diabetics, including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic cardiomyopathy. Patients with type 2 diabetes and diabetic microvascular complications have significantly elevated levels of Asymmetric dimet...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1183586/full |
| _version_ | 1797843249884299264 |
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| author | Xinyang Guo Yiqiao Xing Wei Jin |
| author_facet | Xinyang Guo Yiqiao Xing Wei Jin |
| author_sort | Xinyang Guo |
| collection | DOAJ |
| description | Diabetic microangiopathy is a typical and severe problem in diabetics, including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic cardiomyopathy. Patients with type 2 diabetes and diabetic microvascular complications have significantly elevated levels of Asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide synthase (NOS). ADMA facilitates the occurrence and progression of microvascular complications in type 2 diabetes through its effects on endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This paper reviews the association between ADMA and microvascular complications of diabetes and elucidates the underlying mechanisms by which ADMA contributes to these complications. It provides a new idea and method for the prevention and treatment of microvascular complications in type 2 diabetes. |
| first_indexed | 2024-04-09T17:02:07Z |
| format | Article |
| id | doaj.art-7ad341f65bd74d8ab73bfa7f980aea29 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T17:02:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7ad341f65bd74d8ab73bfa7f980aea292023-04-21T04:44:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11835861183586Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitusXinyang GuoYiqiao XingWei JinDiabetic microangiopathy is a typical and severe problem in diabetics, including diabetic retinopathy, diabetic nephropathy, diabetic neuropathy, and diabetic cardiomyopathy. Patients with type 2 diabetes and diabetic microvascular complications have significantly elevated levels of Asymmetric dimethylarginine (ADMA), which is an endogenous inhibitor of nitric oxide synthase (NOS). ADMA facilitates the occurrence and progression of microvascular complications in type 2 diabetes through its effects on endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This paper reviews the association between ADMA and microvascular complications of diabetes and elucidates the underlying mechanisms by which ADMA contributes to these complications. It provides a new idea and method for the prevention and treatment of microvascular complications in type 2 diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2023.1183586/fulldiabetes mellitusasymmetric dimethylargininemicrovascular complicationsdiabetic retinopathydiabetic nephropathydiabetic neuropathy |
| spellingShingle | Xinyang Guo Yiqiao Xing Wei Jin Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus Frontiers in Endocrinology diabetes mellitus asymmetric dimethylarginine microvascular complications diabetic retinopathy diabetic nephropathy diabetic neuropathy |
| title | Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus |
| title_full | Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus |
| title_fullStr | Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus |
| title_full_unstemmed | Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus |
| title_short | Role of ADMA in the pathogenesis of microvascular complications in type 2 diabetes mellitus |
| title_sort | role of adma in the pathogenesis of microvascular complications in type 2 diabetes mellitus |
| topic | diabetes mellitus asymmetric dimethylarginine microvascular complications diabetic retinopathy diabetic nephropathy diabetic neuropathy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1183586/full |
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