Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility
Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/10/2253 |
| _version_ | 1797551560654323712 |
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| author | Sahar Esfandyari Rishi Man Chugh Hang-soo Park Elie Hobeika Mara Ulin Ayman Al-Hendy |
| author_facet | Sahar Esfandyari Rishi Man Chugh Hang-soo Park Elie Hobeika Mara Ulin Ayman Al-Hendy |
| author_sort | Sahar Esfandyari |
| collection | DOAJ |
| description | Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide. |
| first_indexed | 2024-03-10T15:46:46Z |
| format | Article |
| id | doaj.art-7ad3b65d0e1f4ef9943c00e6cc8ae7ab |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T15:46:46Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7ad3b65d0e1f4ef9943c00e6cc8ae7ab2023-11-20T16:21:49ZengMDPI AGCells2073-44092020-10-01910225310.3390/cells9102253Mesenchymal Stem Cells as a Bio Organ for Treatment of Female InfertilitySahar Esfandyari0Rishi Man Chugh1Hang-soo Park2Elie Hobeika3Mara Ulin4Ayman Al-Hendy5Department of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USADepartment of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USADepartment of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USAFertility Centers of Illinois, Glenview, IL 60026, USADepartment of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USADepartment of Surgery, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USAFemale infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. It affects the quality of life of both patients and couples. Mesenchymal stem cells (MSCs) have received increasing attention as a potential cell-based therapy, with several advantages over other cell sources, including greater abundance, fewer ethical considerations, and high capacity for self-renewal and differentiation. Clinical researchers have examined the therapeutic use of MSCs in female infertility. In this review, we discuss recent studies on the use of MSCs in various reproductive disorders that lead to infertility. We also describe the role of microRNAs (miRNAs) and exosomal miRNAs in controlling MSC gene expression and driving MSC therapeutic outcomes. The clinical application of MSCs holds great promise for the treatment of infertility or ovarian insufficiency, and to improve reproductive health for a significant number of women worldwide.https://www.mdpi.com/2073-4409/9/10/2253infertilitymesenchymal stem cells (MSCs)reproductive systemstem-cell therapy |
| spellingShingle | Sahar Esfandyari Rishi Man Chugh Hang-soo Park Elie Hobeika Mara Ulin Ayman Al-Hendy Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility Cells infertility mesenchymal stem cells (MSCs) reproductive system stem-cell therapy |
| title | Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility |
| title_full | Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility |
| title_fullStr | Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility |
| title_full_unstemmed | Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility |
| title_short | Mesenchymal Stem Cells as a Bio Organ for Treatment of Female Infertility |
| title_sort | mesenchymal stem cells as a bio organ for treatment of female infertility |
| topic | infertility mesenchymal stem cells (MSCs) reproductive system stem-cell therapy |
| url | https://www.mdpi.com/2073-4409/9/10/2253 |
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