Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

ABSTRACTFoot-and-mouth disease (FMD) is one of the most devastating diseases of livestock which can cause significant economic losses, especially when introduced to FMD-free countries. FMD virus (FMDV) belongs to the family Picornaviridae and is antigenically heterogeneous with seven established ser...

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Bibliographic Details
Main Authors: Yunjeong Kim, Emma Pool, Eunji Kim, Chamandi S. Dampalla, Harry Nhat Nguyen, David K. Johnson, Scott Lovell, William C. Groutas, Kyeong-Ok Chang
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
food-and-mouth disease
3C protease
protease inhibitor
antiviral
structure-activity relationships
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03372-23

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