Synthetic Pathways to Pyrido[3,4-<i>c</i>]pyridazines and Their Polycyclic Derivatives

Pyrido[3,4-<i>c</i>]pyridazines are nitrogen-containing scaffolds that have been described as being promising in medicinal chemistry, but they are rather rare chemicals. In this review article, the literature on synthetic pathways towards pyrido[3,4-<i>c</i>]pyridazines is li...

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Bibliographic Details
Main Authors: Temitayo Omowumi Alegbejo Price, Flavio da Silva Emery, Wim Dehaen
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Organics
Subjects:
Online Access:https://www.mdpi.com/2673-401X/3/4/28
Description
Summary:Pyrido[3,4-<i>c</i>]pyridazines are nitrogen-containing scaffolds that have been described as being promising in medicinal chemistry, but they are rather rare chemicals. In this review article, the literature on synthetic pathways towards pyrido[3,4-<i>c</i>]pyridazines is listed exhaustively, first with the bicyclic systems themselves that are obtained starting either from pyridines, pyridazines or other heterocycles. Then, the reports on the related tricyclic derivatives are discussed, again according to the source heterocycle, and finally we mention some examples on polycyclic systems.
ISSN:2673-401X