Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties

Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties

Determining the three-dimensional structure of proteins in their native functional states has been a longstanding challenge in structural biology. While integrative structural biology has been the most effective way to get a high-accuracy structure of different conformations and mechanistic insights...

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Bibliographic Details
Main Authors: Davide Sala, Peter W. Hildebrand, Jens Meiler
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
AlphaFold
GPCRs (G-protein-coupled receptors)
kinases
structure prediction
protein function
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1121962/full

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