Involvement of the kisspeptin system in regulation of sexual behaviors in medaka
Summary: In mammals, kisspeptin (Kiss1) neurons are generally considered as a sex steroid-dependent key regulator of hypothalamic-pituitary-gonadal (HPG) axis. In contrast, previous studies in non-mammalian species, especially in teleosts, propose that Kiss1 is not directly involved in the HPG axis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224001925 |
| _version_ | 1797328603581513728 |
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| author | Mikoto Nakajo Shinji Kanda Yoshitaka Oka |
| author_facet | Mikoto Nakajo Shinji Kanda Yoshitaka Oka |
| author_sort | Mikoto Nakajo |
| collection | DOAJ |
| description | Summary: In mammals, kisspeptin (Kiss1) neurons are generally considered as a sex steroid-dependent key regulator of hypothalamic-pituitary-gonadal (HPG) axis. In contrast, previous studies in non-mammalian species, especially in teleosts, propose that Kiss1 is not directly involved in the HPG axis regulation, which suggests some sex-steroid-dependent functions of kisspeptin(s) other than the HPG axis regulation in non-mammals.Here, we used knockout (KO) medaka of kisspeptin receptor-coding genes (gpr54-1 and gpr54-2) and examined possible roles of kisspeptin in the regulation of sexual behaviors. We found that the KO pairs of gpr54-1, but not gpr54-2, spawned fewer eggs and exhibited delayed spawning than wild type pairs. Detailed behavior analysis suggested that the KO females are responsible for the delayed spawning and that the KO males showed hyper-motivation for courtship. Taken together, the present finding suggests that one of the reproductive-state-dependent functions of the Kiss1 may be the control of successful sexual behaviors. |
| first_indexed | 2024-03-08T06:54:05Z |
| format | Article |
| id | doaj.art-7ad638d1edb54a548355401a2fb33f84 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T06:54:05Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-7ad638d1edb54a548355401a2fb33f842024-02-03T06:39:07ZengElsevieriScience2589-00422024-02-01272108971Involvement of the kisspeptin system in regulation of sexual behaviors in medakaMikoto Nakajo0Shinji Kanda1Yoshitaka Oka2Department of Physiology, Division of Life Sciences, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan; Corresponding authorLaboratory of Physiology, Atmosphere and Ocean Research Institute, The University of Tokyo, Kashiwa, Chiba, JapanDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan; Corresponding authorSummary: In mammals, kisspeptin (Kiss1) neurons are generally considered as a sex steroid-dependent key regulator of hypothalamic-pituitary-gonadal (HPG) axis. In contrast, previous studies in non-mammalian species, especially in teleosts, propose that Kiss1 is not directly involved in the HPG axis regulation, which suggests some sex-steroid-dependent functions of kisspeptin(s) other than the HPG axis regulation in non-mammals.Here, we used knockout (KO) medaka of kisspeptin receptor-coding genes (gpr54-1 and gpr54-2) and examined possible roles of kisspeptin in the regulation of sexual behaviors. We found that the KO pairs of gpr54-1, but not gpr54-2, spawned fewer eggs and exhibited delayed spawning than wild type pairs. Detailed behavior analysis suggested that the KO females are responsible for the delayed spawning and that the KO males showed hyper-motivation for courtship. Taken together, the present finding suggests that one of the reproductive-state-dependent functions of the Kiss1 may be the control of successful sexual behaviors.http://www.sciencedirect.com/science/article/pii/S2589004224001925Biological sciencesDevelopmental biologyMolecular biologyMolecular mechanism of behavior |
| spellingShingle | Mikoto Nakajo Shinji Kanda Yoshitaka Oka Involvement of the kisspeptin system in regulation of sexual behaviors in medaka iScience Biological sciences Developmental biology Molecular biology Molecular mechanism of behavior |
| title | Involvement of the kisspeptin system in regulation of sexual behaviors in medaka |
| title_full | Involvement of the kisspeptin system in regulation of sexual behaviors in medaka |
| title_fullStr | Involvement of the kisspeptin system in regulation of sexual behaviors in medaka |
| title_full_unstemmed | Involvement of the kisspeptin system in regulation of sexual behaviors in medaka |
| title_short | Involvement of the kisspeptin system in regulation of sexual behaviors in medaka |
| title_sort | involvement of the kisspeptin system in regulation of sexual behaviors in medaka |
| topic | Biological sciences Developmental biology Molecular biology Molecular mechanism of behavior |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224001925 |
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