Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy
Abstract The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the angiogenesis factor is balanced by combining with the breathing hyperoxygen, for...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01594-4 |
| _version_ | 1811183283689488384 |
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| author | Ying Zhang Jingyao Zhu Zheng Zhang Dannong He Jun Zhu Yunsheng Chen Yixin Zhang |
| author_facet | Ying Zhang Jingyao Zhu Zheng Zhang Dannong He Jun Zhu Yunsheng Chen Yixin Zhang |
| author_sort | Ying Zhang |
| collection | DOAJ |
| description | Abstract The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the angiogenesis factor is balanced by combining with the breathing hyperoxygen, for regulating the tumor microenvironment and also for relieving hypoxia and high tissue interstitial pressure, which promote drug delivery to tumor tissues by increasing the in vivo perfusion and reversing the immunosuppressive tumor. In addition, the designed multifunctional nanoparticles have a great potential for applications to the tumor dual-mode imaging including magnetic resonance (MR) and photoacoustic (PA) imaging. This work proposes a promising strategy to enhance the thermo/chemo-therapy efficacy by remodeling the tumor microenvironment, which would provide an alternative to prolong the lifetime of tumor patients. Graphical Abstract |
| first_indexed | 2024-04-11T09:45:28Z |
| format | Article |
| id | doaj.art-7ad9db9351cc4108b11eb887bb1e8c0a |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T09:45:28Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-7ad9db9351cc4108b11eb887bb1e8c0a2022-12-22T04:31:05ZengBMCJournal of Nanobiotechnology1477-31552022-08-0120112010.1186/s12951-022-01594-4Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapyYing Zhang0Jingyao Zhu1Zheng Zhang2Dannong He3Jun Zhu4Yunsheng Chen5Yixin Zhang6Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineSchool of Materials Science and Engineering, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineSchool of Materials Science and Engineering, Shanghai Jiao Tong UniversityDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the angiogenesis factor is balanced by combining with the breathing hyperoxygen, for regulating the tumor microenvironment and also for relieving hypoxia and high tissue interstitial pressure, which promote drug delivery to tumor tissues by increasing the in vivo perfusion and reversing the immunosuppressive tumor. In addition, the designed multifunctional nanoparticles have a great potential for applications to the tumor dual-mode imaging including magnetic resonance (MR) and photoacoustic (PA) imaging. This work proposes a promising strategy to enhance the thermo/chemo-therapy efficacy by remodeling the tumor microenvironment, which would provide an alternative to prolong the lifetime of tumor patients. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01594-4Vascular normalizationTumor microenvironmentChemodynamic therapyThermo/chemo-therapyHyperoxygen |
| spellingShingle | Ying Zhang Jingyao Zhu Zheng Zhang Dannong He Jun Zhu Yunsheng Chen Yixin Zhang Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy Journal of Nanobiotechnology Vascular normalization Tumor microenvironment Chemodynamic therapy Thermo/chemo-therapy Hyperoxygen |
| title | Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy |
| title_full | Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy |
| title_fullStr | Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy |
| title_full_unstemmed | Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy |
| title_short | Remodeling of tumor microenvironment for enhanced tumor chemodynamic/photothermal/chemo-therapy |
| title_sort | remodeling of tumor microenvironment for enhanced tumor chemodynamic photothermal chemo therapy |
| topic | Vascular normalization Tumor microenvironment Chemodynamic therapy Thermo/chemo-therapy Hyperoxygen |
| url | https://doi.org/10.1186/s12951-022-01594-4 |
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