Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study
A well-synchronized circadian system is a manifestation of an individual's health. A gradual weakening of the circadian timing function characterizes aging. Regular exercise has been suggested as a modality to improve many detrimental changes associated with aging. Therefore, we aim to examine...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2023-12-01
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| Series: | European Journal of Translational Myology |
| Subjects: | |
| Online Access: | https://www.pagepressjournals.org/index.php/bam/article/view/12012 |
| _version_ | 1797403782171066368 |
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| author | Genc Berisha Milan Sedliak Michal Zeman Dušan Hamar Ján Cvečka Veronika Tirpáková Matej Vajda Ľudmila Oreská Alena Černáčková Martin Čupka Nejc Šarabon Feliciano Protasi Sandra Zampieri Helmut Kern Stefan Lofler Antonio Musaro Katarína Stebelová Monika Okuliarová |
| author_facet | Genc Berisha Milan Sedliak Michal Zeman Dušan Hamar Ján Cvečka Veronika Tirpáková Matej Vajda Ľudmila Oreská Alena Černáčková Martin Čupka Nejc Šarabon Feliciano Protasi Sandra Zampieri Helmut Kern Stefan Lofler Antonio Musaro Katarína Stebelová Monika Okuliarová |
| author_sort | Genc Berisha |
| collection | DOAJ |
| description |
A well-synchronized circadian system is a manifestation of an individual's health. A gradual weakening of the circadian timing function characterizes aging. Regular exercise has been suggested as a modality to improve many detrimental changes associated with aging. Therefore, we aim to examine the benefits and risks of lifelong endurance exercise on age-dependent changes in the circadian time-keeping function, the performance of the muscular system and health status. The study protocol has a comparative cross-sectional design, including groups of senior (65 to 75 years old, n=16) and young (20-30 years old, n=16) endurance runners and triathletes. Age-matched groups of young and elderly sedentary men are included as controls. The circadian function is evaluated mainly by measurement of urinary 6-sulphatoxymelatonin, a metabolite of the hormone melatonin shown to participate in the modulation of sleep cycles. The 6-sulphatoxymelatonin will be assessed in urine samples collected upon awakening in the morning and in the late evening, as a marker of melatonin production. In addition, sleep/activity rhythms and sleep quality will be measured by wrist actigraphy. Performance of the muscular system will be assessed by examination of muscular strength and quantifying of gene expression in the skeletal muscle tissue samples. Health status and age-induced reduction in immune function are to be analysed via the balance of pro- and anti-inflammatory immune markers in the plasma and skeletal muscle, body composition, bone density and physical fitness.
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| first_indexed | 2024-03-09T02:43:21Z |
| format | Article |
| id | doaj.art-7ada1743e02b4f6db6002479d0a364bd |
| institution | Directory Open Access Journal |
| issn | 2037-7452 2037-7460 |
| language | English |
| last_indexed | 2024-03-09T02:43:21Z |
| publishDate | 2023-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj.art-7ada1743e02b4f6db6002479d0a364bd2023-12-05T23:05:45ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602023-12-0110.4081/ejtm.2023.12012Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional studyGenc Berisha0Milan Sedliak1Michal Zeman2Dušan Hamar3Ján Cvečka4Veronika Tirpáková5Matej Vajda6Ľudmila Oreská7Alena Černáčková8Martin Čupka9Nejc Šarabon10Feliciano Protasi11Sandra Zampieri12Helmut Kern13Stefan Lofler14Antonio Musaro15Katarína Stebelová16Monika Okuliarová17Comenius University in Bratislava, Faculty of Physical Education and Sport, Department of Biological and Medical SciencesComenius University in Bratislava, Faculty of Physical Education and Sport, Department of Biological and Medical SciencesComenius University in Bratislava, Faculty of Natural Sciences, Department of Animal Physiology and EthologyComenius University in Bratislava, Faculty of Physical Education and Sport, Department of Biological and Medical SciencesComenius University in Bratislava, Faculty of Physical Education and Sport, Professor Hamar Diagnostic CentreComenius University in Bratislava, Faculty of Physical Education and Sport, Professor Hamar Diagnostic CentreComenius University in Bratislava, Faculty of Physical Education and Sport, Professor Hamar Diagnostic CentreComenius University in Bratislava, Faculty of Physical Education and Sport, Department of Biological and Medical SciencesComenius University in Bratislava, Faculty of Physical Education and Sport, Department of Biological and Medical SciencesComenius University in Bratislava, Faculty of Physical Education and Sport, Department of Biological and Medical SciencesUniversity of Primorska, Faculty of Health SciencesGabriele d'Annunzio University of Chieti and Pescara, Center for Advanced Studies and Technology, Department of Medicine and Aging SciencesUniversity of Padova, Department of Surgery, Oncology and Gastroenterology, Department of Biomedical SciencesLudwig Boltzmann Institute for Rehabilitation Research, St. Pölten, Austria and 2. Physiko- und RheumatherapieLudwig Boltzmann Institute for Rehabilitation Research, St. Pölten, Austria and 2. Physiko- und RheumatherapieUniversity of Rome La Sapienza, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, Scuola Superiore di Studi Avanzati SapienzaComenius University in Bratislava, Faculty of Natural Sciences, Department of Animal Physiology and EthologyComenius University in Bratislava, Faculty of Natural Sciences, Department of Animal Physiology and Ethology A well-synchronized circadian system is a manifestation of an individual's health. A gradual weakening of the circadian timing function characterizes aging. Regular exercise has been suggested as a modality to improve many detrimental changes associated with aging. Therefore, we aim to examine the benefits and risks of lifelong endurance exercise on age-dependent changes in the circadian time-keeping function, the performance of the muscular system and health status. The study protocol has a comparative cross-sectional design, including groups of senior (65 to 75 years old, n=16) and young (20-30 years old, n=16) endurance runners and triathletes. Age-matched groups of young and elderly sedentary men are included as controls. The circadian function is evaluated mainly by measurement of urinary 6-sulphatoxymelatonin, a metabolite of the hormone melatonin shown to participate in the modulation of sleep cycles. The 6-sulphatoxymelatonin will be assessed in urine samples collected upon awakening in the morning and in the late evening, as a marker of melatonin production. In addition, sleep/activity rhythms and sleep quality will be measured by wrist actigraphy. Performance of the muscular system will be assessed by examination of muscular strength and quantifying of gene expression in the skeletal muscle tissue samples. Health status and age-induced reduction in immune function are to be analysed via the balance of pro- and anti-inflammatory immune markers in the plasma and skeletal muscle, body composition, bone density and physical fitness. https://www.pagepressjournals.org/index.php/bam/article/view/12012Circadianagingexercisesports medicinemolecular biologysleep/wake rhythm |
| spellingShingle | Genc Berisha Milan Sedliak Michal Zeman Dušan Hamar Ján Cvečka Veronika Tirpáková Matej Vajda Ľudmila Oreská Alena Černáčková Martin Čupka Nejc Šarabon Feliciano Protasi Sandra Zampieri Helmut Kern Stefan Lofler Antonio Musaro Katarína Stebelová Monika Okuliarová Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study European Journal of Translational Myology Circadian aging exercise sports medicine molecular biology sleep/wake rhythm |
| title | Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study |
| title_full | Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study |
| title_fullStr | Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study |
| title_full_unstemmed | Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study |
| title_short | Can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function, muscular performance and health status in men? Protocol for a comparative cross-sectional study |
| title_sort | can lifelong endurance exercise improve ageing through beneficial effects on circadian timing function muscular performance and health status in men protocol for a comparative cross sectional study |
| topic | Circadian aging exercise sports medicine molecular biology sleep/wake rhythm |
| url | https://www.pagepressjournals.org/index.php/bam/article/view/12012 |
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