High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis

Abstract Activation of the key nutrient cellular sensors mTORC1 and mTORC2 directs the fate of mesenchymal stromal cells (MSCs). Here, we report that glutamine regulates crosstalk between mTOR complexes and lineage commitment of MSCs independent of glucose concentration. High glutamine-induced mTORC...

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Bibliographic Details
Main Authors: Meher Bolisetti Gayatri, Navya Naidu Gajula, Suresh Chava, Aramati B. M. Reddy
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01077-3

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