Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mechanisms and, if deregulated, they can lead to cancer...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-05-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223004191 |
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| author | David Sánchez-Marín Macrina Beatriz Silva-Cázares Fany Iris Porras-Reyes Rebeca García-Román Alma D. Campos-Parra |
| author_facet | David Sánchez-Marín Macrina Beatriz Silva-Cázares Fany Iris Porras-Reyes Rebeca García-Román Alma D. Campos-Parra |
| author_sort | David Sánchez-Marín |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mechanisms and, if deregulated, they can lead to cancer development and progression. Recently, it has been described that lncRNAs are susceptible to form gene fusions with mRNAs or other lncRNAs, breaking the paradigm of gene fusions consisting mainly of protein-coding genes. However, their biological significance in the tumor phenotype is still uncertain. Therefore, their recent identification opens a new line of research to study their biological role in tumorigenesis, and their potential as biomarkers with clinical relevance or as therapeutic targets. The present study aimed to review the lncRNA fusions identified so far and to know which of them have been associated with a potential function. We address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window in cancer. |
| first_indexed | 2024-03-07T21:43:34Z |
| format | Article |
| id | doaj.art-7addc0437a1045fc90dccb3ee13eb4e8 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T03:33:25Z |
| publishDate | 2024-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-7addc0437a1045fc90dccb3ee13eb4e82024-04-28T12:19:57ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-05-01113101136Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancerDavid Sánchez-Marín0Macrina Beatriz Silva-Cázares1Fany Iris Porras-Reyes2Rebeca García-Román3Alma D. Campos-Parra4Posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, C.P. 04360, MéxicoUnidad Académica Multidisciplinaria Región Altiplano, Universidad Autónoma de San Luis Potosí (UASLP), Carretera a Cedral Km 5+600, Ejido San José de la Trojes, Matehuala, San Luis Potosí, C.P. 78760, MéxicoServicio de Anatomía Patológica, Instituto Nacional de Cancerología (INCan), Niño Jesús, Tlalpan, Ciudad de México, C.P. 14080, MéxicoInstituto de Salud Pública, Universidad Veracruzana (UV), Av. Dr Luis, Dr. Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa, Veracruz, C.P. 91190, MéxicoInstituto de Salud Pública, Universidad Veracruzana (UV), Av. Dr Luis, Dr. Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa, Veracruz, C.P. 91190, México; Corresponding author.Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mechanisms and, if deregulated, they can lead to cancer development and progression. Recently, it has been described that lncRNAs are susceptible to form gene fusions with mRNAs or other lncRNAs, breaking the paradigm of gene fusions consisting mainly of protein-coding genes. However, their biological significance in the tumor phenotype is still uncertain. Therefore, their recent identification opens a new line of research to study their biological role in tumorigenesis, and their potential as biomarkers with clinical relevance or as therapeutic targets. The present study aimed to review the lncRNA fusions identified so far and to know which of them have been associated with a potential function. We address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window in cancer.http://www.sciencedirect.com/science/article/pii/S2352304223004191CancerGene fusionslncRNAsncRNAsTherapy |
| spellingShingle | David Sánchez-Marín Macrina Beatriz Silva-Cázares Fany Iris Porras-Reyes Rebeca García-Román Alma D. Campos-Parra Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer Genes and Diseases Cancer Gene fusions lncRNAs ncRNAs Therapy |
| title | Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer |
| title_full | Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer |
| title_fullStr | Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer |
| title_full_unstemmed | Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer |
| title_short | Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer |
| title_sort | breaking paradigms long non coding rnas forming gene fusions with potential implications in cancer |
| topic | Cancer Gene fusions lncRNAs ncRNAs Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223004191 |
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