Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female

Vitiligo, particularly the rarer inflammatory variant, may be difficult to distinguish from hypopigmented mycosis fungoides (MF) clinically. Complicating the distinction is that when biopsies are taken from the periphery of early vitiliginous lesions or from lesions with an inflammatory border (infl...

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Main Authors: Luis A Soro, Anthony J Gust, Stephen M Purcell
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Indian Dermatology Online Journal
Subjects:
Online Access:http://www.idoj.in/article.asp?issn=2229-5178;year=2013;volume=4;issue=4;spage=321;epage=325;aulast=Soro
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author Luis A Soro
Anthony J Gust
Stephen M Purcell
author_facet Luis A Soro
Anthony J Gust
Stephen M Purcell
author_sort Luis A Soro
collection DOAJ
description Vitiligo, particularly the rarer inflammatory variant, may be difficult to distinguish from hypopigmented mycosis fungoides (MF) clinically. Complicating the distinction is that when biopsies are taken from the periphery of early vitiliginous lesions or from lesions with an inflammatory border (inflammatory vitiligo), a dermal lymphocytic infiltrate, exocytosis, interface dermatitis, and mild spongiosis may be seen, all resembling the findings seen in hypopigmented MF. We present a case demonstrating the difficulty in differentiating between these two diseases and examine some characteristic clinical and histopathological features of each. Often, a conclusive diagnosis cannot be made, necessitating close follow-up of the patient and monitoring for progression of their disease over time.
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spelling doaj.art-7ade96f365b0479c9603e3c831b3e5762022-12-22T02:55:00ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782013-01-014432132510.4103/2229-5178.120662Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian femaleLuis A SoroAnthony J GustStephen M PurcellVitiligo, particularly the rarer inflammatory variant, may be difficult to distinguish from hypopigmented mycosis fungoides (MF) clinically. Complicating the distinction is that when biopsies are taken from the periphery of early vitiliginous lesions or from lesions with an inflammatory border (inflammatory vitiligo), a dermal lymphocytic infiltrate, exocytosis, interface dermatitis, and mild spongiosis may be seen, all resembling the findings seen in hypopigmented MF. We present a case demonstrating the difficulty in differentiating between these two diseases and examine some characteristic clinical and histopathological features of each. Often, a conclusive diagnosis cannot be made, necessitating close follow-up of the patient and monitoring for progression of their disease over time.http://www.idoj.in/article.asp?issn=2229-5178;year=2013;volume=4;issue=4;spage=321;epage=325;aulast=SoroCutaneous T-cell lymphomahypopigmented mycosis fungoidesinflammatory vitiligo
spellingShingle Luis A Soro
Anthony J Gust
Stephen M Purcell
Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female
Indian Dermatology Online Journal
Cutaneous T-cell lymphoma
hypopigmented mycosis fungoides
inflammatory vitiligo
title Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female
title_full Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female
title_fullStr Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female
title_full_unstemmed Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female
title_short Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female
title_sort inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58 year old indian female
topic Cutaneous T-cell lymphoma
hypopigmented mycosis fungoides
inflammatory vitiligo
url http://www.idoj.in/article.asp?issn=2229-5178;year=2013;volume=4;issue=4;spage=321;epage=325;aulast=Soro
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AT anthonyjgust inflammatoryvitiligoversushypopigmentedmycosisfungoidesina58yearoldindianfemale
AT stephenmpurcell inflammatoryvitiligoversushypopigmentedmycosisfungoidesina58yearoldindianfemale