Large-scale design and refinement of stable proteins using sequence-only models.

Large-scale design and refinement of stable proteins using sequence-only models.

Show other versions (1)

Engineered proteins generally must possess a stable structure in order to achieve their designed function. Stable designs, however, are astronomically rare within the space of all possible amino acid sequences. As a consequence, many designs must be tested computationally and experimentally in order...

Full description

Bibliographic Details
Main Authors: Jedediah M Singer, Scott Novotney, Devin Strickland, Hugh K Haddox, Nicholas Leiby, Gabriel J Rocklin, Cameron M Chow, Anindya Roy, Asim K Bera, Francis C Motta, Longxing Cao, Eva-Maria Strauch, Tamuka M Chidyausiku, Alex Ford, Ethan Ho, Alexander Zaitzeff, Craig O Mackenzie, Hamed Eramian, Frank DiMaio, Gevorg Grigoryan, Matthew Vaughn, Lance J Stewart, David Baker, Eric Klavins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0265020

Internet

https://doi.org/10.1371/journal.pone.0265020

Similar Items