Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance?
Amoebiasis caused by Entamoeba histolytica (E. histolytica) is one of the most problematic parasitic infections worldwide. Data regarding the effect of HIV-induced immunodeficiency on the status of E. histolytica infection are sparse in Iran. This study aimed to assess the seroprevalence of anti-E....
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-01-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4937 |
| _version_ | 1811293642626695168 |
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| author | Alireza Abdollahi Hana Saffar Hiva Saffar Sara Sheikhbahaei Mehrnaz Rasoulinejad |
| author_facet | Alireza Abdollahi Hana Saffar Hiva Saffar Sara Sheikhbahaei Mehrnaz Rasoulinejad |
| author_sort | Alireza Abdollahi |
| collection | DOAJ |
| description | Amoebiasis caused by Entamoeba histolytica (E. histolytica) is one of the most problematic parasitic infections worldwide. Data regarding the effect of HIV-induced immunodeficiency on the status of E. histolytica infection are sparse in Iran. This study aimed to assess the seroprevalence of anti-E. histolytica IgG among Iranian HIV patients. Further, it determined whether the advancement of immunodeficiency accompanies an increased risk of amoebiasis. A total of 91 HIV-infected patients and 91 controls were enrolled in this case-control study. Controls were matched to cases with respect to age, gender, and where possible socioeconomic status. Patients with a history of treatment for intestinal parasitism within last two weeks were not included in the study. Blood samples were obtained from all participants. Serum IgG against E. histolytica measured using a commercial enzyme-linked immunosorbent assay (ELISA). The mean serum anti-E. histolytica IgG was significantly higher in HIV patients than controls (9.34 ± 4.18 vs. 2.07 ± 0.60, P<0.001). HIV-infected patients showed a significantly higher positive serology for E. histolytica IgG comparing healthy controls (30.8% vs. 0% P<0.001). There was no statistical difference in the serology of E. histolytica among AIDS stage and non-AIDS HIV patients. This study demonstrated that HIV is significantly associated with higher prevalence of E. histolytica infection. Early evaluation and treatment of E. histolytica in this population is recommended to prevent and control this infection. |
| first_indexed | 2024-04-13T05:04:34Z |
| format | Article |
| id | doaj.art-7adf25c8dd22453b947abab68bfd78e5 |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-04-13T05:04:34Z |
| publishDate | 2015-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-7adf25c8dd22453b947abab68bfd78e52022-12-22T03:01:13ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942015-01-015314890Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance?Alireza Abdollahi0Hana Saffar1Hiva Saffar2Sara Sheikhbahaei3Mehrnaz Rasoulinejad4Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. AND Thrombosis Hemostasis Research Center, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Department of Infectious Diseases, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.Amoebiasis caused by Entamoeba histolytica (E. histolytica) is one of the most problematic parasitic infections worldwide. Data regarding the effect of HIV-induced immunodeficiency on the status of E. histolytica infection are sparse in Iran. This study aimed to assess the seroprevalence of anti-E. histolytica IgG among Iranian HIV patients. Further, it determined whether the advancement of immunodeficiency accompanies an increased risk of amoebiasis. A total of 91 HIV-infected patients and 91 controls were enrolled in this case-control study. Controls were matched to cases with respect to age, gender, and where possible socioeconomic status. Patients with a history of treatment for intestinal parasitism within last two weeks were not included in the study. Blood samples were obtained from all participants. Serum IgG against E. histolytica measured using a commercial enzyme-linked immunosorbent assay (ELISA). The mean serum anti-E. histolytica IgG was significantly higher in HIV patients than controls (9.34 ± 4.18 vs. 2.07 ± 0.60, P<0.001). HIV-infected patients showed a significantly higher positive serology for E. histolytica IgG comparing healthy controls (30.8% vs. 0% P<0.001). There was no statistical difference in the serology of E. histolytica among AIDS stage and non-AIDS HIV patients. This study demonstrated that HIV is significantly associated with higher prevalence of E. histolytica infection. Early evaluation and treatment of E. histolytica in this population is recommended to prevent and control this infection.https://acta.tums.ac.ir/index.php/acta/article/view/4937Entamoeba histolyticaSeroprevalenceHIV infection |
| spellingShingle | Alireza Abdollahi Hana Saffar Hiva Saffar Sara Sheikhbahaei Mehrnaz Rasoulinejad Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance? Acta Medica Iranica Entamoeba histolytica Seroprevalence HIV infection |
| title | Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance? |
| title_full | Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance? |
| title_fullStr | Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance? |
| title_full_unstemmed | Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance? |
| title_short | Is the Evaluation of Entamoeba Histolytica Infection in HIV-Positive Patients of any Clinical Significance? |
| title_sort | is the evaluation of entamoeba histolytica infection in hiv positive patients of any clinical significance |
| topic | Entamoeba histolytica Seroprevalence HIV infection |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4937 |
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