Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases
This work investigates the possibility of using thiolated silicone oils as new components in protective creams and their impact on the efficacy of these products. Thiolated silicone oils were synthesized by amide bond formation between primary amino groups of poly17dimethylsiloxane-co-(3-aminopropyl...
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2021-08-01
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| Online Access: | https://www.mdpi.com/1996-1944/14/16/4723 |
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| author | Agnieszka Kulawik-Pióro Anna K. Drabczyk Joanna Kruk Magdalena Wróblewska Katarzyna Winnicka Justyna Tchórzewska |
| author_facet | Agnieszka Kulawik-Pióro Anna K. Drabczyk Joanna Kruk Magdalena Wróblewska Katarzyna Winnicka Justyna Tchórzewska |
| author_sort | Agnieszka Kulawik-Pióro |
| collection | DOAJ |
| description | This work investigates the possibility of using thiolated silicone oils as new components in protective creams and their impact on the efficacy of these products. Thiolated silicone oils were synthesized by amide bond formation between primary amino groups of poly17dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane] and carboxylic groups of thiol ligand (3-mercaptopropionic acid) with carbodiimide as a coupling agent. To evaluate and compare the properties of these kinds of thiomers, three different emulsion o/w types were obtained. Emulsion E1 contained methyl silicone oil, E2 poly[dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane], and E3 thiolated silicone oil (silicone-MPA), respectively. Physicochemical properties, including pH, conductivity, droplet size distribution, viscosity, and stability, were assessed. The efficacy of barrier creams in the prevention of occupational skin diseases depends on their mechanical and rheological properties. Thus, the method which imitates the spreadability conditions on the skin and how structure reconstruction takes places was performed. We also investigated textural profile, bioadhesion, protection against water and detergents, and water vapor permeability. Emulsion E3 was characterized by beneficial occlusion, spreadability, and adhesion properties. These features with prolonged residence time on the skin can make designed barrier creams more preferable for consumers. |
| first_indexed | 2024-03-10T08:38:10Z |
| format | Article |
| id | doaj.art-7ae18c556768418ebe82647d3b023ce2 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T08:38:10Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-7ae18c556768418ebe82647d3b023ce22023-11-22T08:31:55ZengMDPI AGMaterials1996-19442021-08-011416472310.3390/ma14164723Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin DiseasesAgnieszka Kulawik-Pióro0Anna K. Drabczyk1Joanna Kruk2Magdalena Wróblewska3Katarzyna Winnicka4Justyna Tchórzewska5Department of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, PolandDepartment of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Warszawska 24, 31-155 Kraków, PolandDepartment of Engineering and Machinery for Food Industry, Faculty of Food Technology, University of Agriculture in Kraków, Balicka 122, 30-149 Kraków, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical Univeristy of Białystok, Mickiewicza 2C, 15-222 Białystok, PolandDepartment of Pharmaceutical Technology, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical Univeristy of Białystok, Mickiewicza 2C, 15-222 Białystok, PolandLubricant Supply Chain, Shell Business Operations Poland, Czerwone Maki 87, 30-392 Kraków, PolandThis work investigates the possibility of using thiolated silicone oils as new components in protective creams and their impact on the efficacy of these products. Thiolated silicone oils were synthesized by amide bond formation between primary amino groups of poly17dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane] and carboxylic groups of thiol ligand (3-mercaptopropionic acid) with carbodiimide as a coupling agent. To evaluate and compare the properties of these kinds of thiomers, three different emulsion o/w types were obtained. Emulsion E1 contained methyl silicone oil, E2 poly[dimethylsiloxane-co-(3-aminopropyl)-methylsiloxane], and E3 thiolated silicone oil (silicone-MPA), respectively. Physicochemical properties, including pH, conductivity, droplet size distribution, viscosity, and stability, were assessed. The efficacy of barrier creams in the prevention of occupational skin diseases depends on their mechanical and rheological properties. Thus, the method which imitates the spreadability conditions on the skin and how structure reconstruction takes places was performed. We also investigated textural profile, bioadhesion, protection against water and detergents, and water vapor permeability. Emulsion E3 was characterized by beneficial occlusion, spreadability, and adhesion properties. These features with prolonged residence time on the skin can make designed barrier creams more preferable for consumers.https://www.mdpi.com/1996-1944/14/16/4723barrier creams (BC), thiomerssilicone oilskin adhesiveskin barrier functionocclusionprotective preparations |
| spellingShingle | Agnieszka Kulawik-Pióro Anna K. Drabczyk Joanna Kruk Magdalena Wróblewska Katarzyna Winnicka Justyna Tchórzewska Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases Materials barrier creams (BC), thiomers silicone oil skin adhesive skin barrier function occlusion protective preparations |
| title | Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases |
| title_full | Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases |
| title_fullStr | Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases |
| title_full_unstemmed | Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases |
| title_short | Thiolated Silicone Oils as New Components of Protective Creams in the Prevention of Skin Diseases |
| title_sort | thiolated silicone oils as new components of protective creams in the prevention of skin diseases |
| topic | barrier creams (BC), thiomers silicone oil skin adhesive skin barrier function occlusion protective preparations |
| url | https://www.mdpi.com/1996-1944/14/16/4723 |
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