Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan
Abstract COVID-19 is a viral infection and does not require antibiotics. The study aimed to elucidate a prescribing pattern of antibiotics for COVID-19. A nationwide cross-sectional study was conducted in Japan. The Diagnosis and Procedure Combinations (DPC) data was used to collect information, cov...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-26780-0 |
| _version_ | 1797973638439239680 |
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| author | Seiji Hamada Yasuharu Tokuda Hitoshi Honda Takashi Watari Tomoharu Suzuki Takuhiro Moromizato Masashi Narita Kiyosu Taniguchi Kenji Shibuya |
| author_facet | Seiji Hamada Yasuharu Tokuda Hitoshi Honda Takashi Watari Tomoharu Suzuki Takuhiro Moromizato Masashi Narita Kiyosu Taniguchi Kenji Shibuya |
| author_sort | Seiji Hamada |
| collection | DOAJ |
| description | Abstract COVID-19 is a viral infection and does not require antibiotics. The study aimed to elucidate a prescribing pattern of antibiotics for COVID-19. A nationwide cross-sectional study was conducted in Japan. The Diagnosis and Procedure Combinations (DPC) data was used to collect information, covering 25% of all acute care hospitals in the country. In 140,439 COVID-19 patients, 18,550 (13.21%) patients received antibiotics. Antibiotics were prescribed more often in inpatients (10,809 out of 66,912, 16.15%) than outpatients (7741 out of 73,527, 10.53%) (p < 0.001). Outpatient prescription was significantly associated with older patients (odds ratio [OR], 4.66; 95% confidence interval [CI] 4.41–4.93) and a greater Charlson index (OR with one-point index increase, 1.22; 95% CI 1.21–1.23). Inpatient prescription was significantly associated with older patients (OR 2.10; 95% CI 2.01–2.21), male gender (OR 1.12, 95% CI 1.07–1.18), a greater Charlson index (OR with one-point increase, 1.06; 95% CI 1.05–1.07), requirement of oxygen therapy (OR 3.44; 95% CI 3.28–3.60) and mechanical ventilation (OR 15.09; 95% CI 13.60–16.74). The most frequently prescribed antibiotic among outpatients was cefazolin, while that among inpatients was ceftriaxone. Antibiotic prescription is relatively low for acute COVID-19 in Japan. Antibiotic prescription was associated with older age, multi-morbidity, severe disease, and winter season. |
| first_indexed | 2024-04-11T04:07:27Z |
| format | Article |
| id | doaj.art-7ae1ce1a5e4243b6bab529440202d501 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T04:07:27Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7ae1ce1a5e4243b6bab529440202d5012023-01-01T12:19:54ZengNature PortfolioScientific Reports2045-23222022-12-011211610.1038/s41598-022-26780-0Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in JapanSeiji Hamada0Yasuharu Tokuda1Hitoshi Honda2Takashi Watari3Tomoharu Suzuki4Takuhiro Moromizato5Masashi Narita6Kiyosu Taniguchi7Kenji Shibuya8Urasoe General HospitalThe Tokyo Foundation for Policy ResearchFujita Medical UniversityGeneral Medicine Center, Shimane UniversityUrasoe General HospitalOkinawa Prefectural Nanbu Medical Center & Children’s Medical CenterOkinawa Prefectural Nanbu Medical Center & Children’s Medical CenterThe Tokyo Foundation for Policy ResearchThe Tokyo Foundation for Policy ResearchAbstract COVID-19 is a viral infection and does not require antibiotics. The study aimed to elucidate a prescribing pattern of antibiotics for COVID-19. A nationwide cross-sectional study was conducted in Japan. The Diagnosis and Procedure Combinations (DPC) data was used to collect information, covering 25% of all acute care hospitals in the country. In 140,439 COVID-19 patients, 18,550 (13.21%) patients received antibiotics. Antibiotics were prescribed more often in inpatients (10,809 out of 66,912, 16.15%) than outpatients (7741 out of 73,527, 10.53%) (p < 0.001). Outpatient prescription was significantly associated with older patients (odds ratio [OR], 4.66; 95% confidence interval [CI] 4.41–4.93) and a greater Charlson index (OR with one-point index increase, 1.22; 95% CI 1.21–1.23). Inpatient prescription was significantly associated with older patients (OR 2.10; 95% CI 2.01–2.21), male gender (OR 1.12, 95% CI 1.07–1.18), a greater Charlson index (OR with one-point increase, 1.06; 95% CI 1.05–1.07), requirement of oxygen therapy (OR 3.44; 95% CI 3.28–3.60) and mechanical ventilation (OR 15.09; 95% CI 13.60–16.74). The most frequently prescribed antibiotic among outpatients was cefazolin, while that among inpatients was ceftriaxone. Antibiotic prescription is relatively low for acute COVID-19 in Japan. Antibiotic prescription was associated with older age, multi-morbidity, severe disease, and winter season.https://doi.org/10.1038/s41598-022-26780-0 |
| spellingShingle | Seiji Hamada Yasuharu Tokuda Hitoshi Honda Takashi Watari Tomoharu Suzuki Takuhiro Moromizato Masashi Narita Kiyosu Taniguchi Kenji Shibuya Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan Scientific Reports |
| title | Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan |
| title_full | Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan |
| title_fullStr | Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan |
| title_full_unstemmed | Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan |
| title_short | Prevalence and characteristics of antibiotic prescription for acute COVID-19 patients in Japan |
| title_sort | prevalence and characteristics of antibiotic prescription for acute covid 19 patients in japan |
| url | https://doi.org/10.1038/s41598-022-26780-0 |
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