Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies
Knee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809917301443 |
| _version_ | 1828527203638312960 |
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| author | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin |
| author_facet | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin |
| author_sort | Jorge L. Escobar Ivirico |
| collection | DOAJ |
| description | Knee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have been beneficial in treating the disease but none is as effective as total knee arthroplasty (TKA). However, while TKA is an end-stage solution of the disease, it is an invasive and expensive procedure. Therefore, innovative regenerative engineering strategies should be established as these could defer or annul the need for a TKA. Several biomaterial and cell-based therapies are currently in development and have shown early promise in both preclinical and clinical studies. The use of advanced biomaterials and stem cells independently or in conjunction to treat knee OA could potentially reduce pain and regenerate focal articular cartilage damage. In this review, we discuss the pathogenesis of pain and cartilage damage in knee OA and explore novel treatment options currently being studied, along with some of their limitations. |
| first_indexed | 2024-12-11T21:35:52Z |
| format | Article |
| id | doaj.art-7ae1d956dbc64db09a6c9793f4bc2f2a |
| institution | Directory Open Access Journal |
| issn | 2095-8099 |
| language | English |
| last_indexed | 2024-12-11T21:35:52Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering |
| spelling | doaj.art-7ae1d956dbc64db09a6c9793f4bc2f2a2022-12-22T00:50:00ZengElsevierEngineering2095-80992017-02-0131162710.1016/J.ENG.2017.01.003Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based TechnologiesJorge L. Escobar Ivirico0Maumita Bhattacharjee1Emmanuel Kuyinu2Lakshmi S. Nair3Cato T. Laurencin4Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USAInstitute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USAInstitute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USAInstitute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USAInstitute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USAKnee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have been beneficial in treating the disease but none is as effective as total knee arthroplasty (TKA). However, while TKA is an end-stage solution of the disease, it is an invasive and expensive procedure. Therefore, innovative regenerative engineering strategies should be established as these could defer or annul the need for a TKA. Several biomaterial and cell-based therapies are currently in development and have shown early promise in both preclinical and clinical studies. The use of advanced biomaterials and stem cells independently or in conjunction to treat knee OA could potentially reduce pain and regenerate focal articular cartilage damage. In this review, we discuss the pathogenesis of pain and cartilage damage in knee OA and explore novel treatment options currently being studied, along with some of their limitations.http://www.sciencedirect.com/science/article/pii/S2095809917301443Knee osteoarthritisOsteoarthritic painMesenchymal stem cellsBiomaterialsRegenerative engineering |
| spellingShingle | Jorge L. Escobar Ivirico Maumita Bhattacharjee Emmanuel Kuyinu Lakshmi S. Nair Cato T. Laurencin Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies Engineering Knee osteoarthritis Osteoarthritic pain Mesenchymal stem cells Biomaterials Regenerative engineering |
| title | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
| title_full | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
| title_fullStr | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
| title_full_unstemmed | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
| title_short | Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies |
| title_sort | regenerative engineering for knee osteoarthritis treatment biomaterials and cell based technologies |
| topic | Knee osteoarthritis Osteoarthritic pain Mesenchymal stem cells Biomaterials Regenerative engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2095809917301443 |
| work_keys_str_mv | AT jorgelescobarivirico regenerativeengineeringforkneeosteoarthritistreatmentbiomaterialsandcellbasedtechnologies AT maumitabhattacharjee regenerativeengineeringforkneeosteoarthritistreatmentbiomaterialsandcellbasedtechnologies AT emmanuelkuyinu regenerativeengineeringforkneeosteoarthritistreatmentbiomaterialsandcellbasedtechnologies AT lakshmisnair regenerativeengineeringforkneeosteoarthritistreatmentbiomaterialsandcellbasedtechnologies AT catotlaurencin regenerativeengineeringforkneeosteoarthritistreatmentbiomaterialsandcellbasedtechnologies |