Thyroid and renal cancers: A bidirectional association
There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.951976/full |
| _version_ | 1828412938188226560 |
|---|---|
| author | Maria Irene Bellini Eleonora Lori Flavio Forte Augusto Lauro Domenico Tripodi Maria Ida Amabile Vito Cantisani Marzia Varanese Iulia Catalina Ferent Enke Baldini Salvatore Ulisse Vito D’Andrea Daniele Pironi Salvatore Sorrenti |
| author_facet | Maria Irene Bellini Eleonora Lori Flavio Forte Augusto Lauro Domenico Tripodi Maria Ida Amabile Vito Cantisani Marzia Varanese Iulia Catalina Ferent Enke Baldini Salvatore Ulisse Vito D’Andrea Daniele Pironi Salvatore Sorrenti |
| author_sort | Maria Irene Bellini |
| collection | DOAJ |
| description | There is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several malignancies, such as breast cancer, prostate cancer, colorectal cancer, and other, with an increased risk of kidney disease, public health alert for these conditions is warranted. A systematic review of the current evidence on the bidirectional relationship between thyroid and renal cancers was conducted including 18 studies, highlighting patient’s characteristics, histology, time for secondary malignancy to develop from the first diagnosis, treatment, and follow-up. A total of 776 patients were identified; median age was 64 years (range: 7–76 years). Obesity and family history were identified as the most common risk factors, and genetic susceptibility was suggested with a potential strong association with Cowden syndrome. Controversy on chemo and radiotherapy effects was found, as not all patients were previously exposed to these treatments. Men were more likely to develop kidney cancer after a primary thyroid malignancy, with 423/776 (54%) experiencing renal disease secondarily. Median time after the first malignancy was 5.2 years (range: 0–20 years). With the advancement of current oncological therapy, the prognosis for thyroid cancer patients has improved, although there has been a corresponding rise in the incidence of multiple secondary malignancy within the same population, particularly concerning the kidney. Surgery can achieve disease-free survival, if surveillance follow-up allows for an early localized form, where radical treatment is recommended. |
| first_indexed | 2024-12-10T12:58:23Z |
| format | Article |
| id | doaj.art-7ae32746b21f4191bd84b05c1f8333b1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T12:58:23Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7ae32746b21f4191bd84b05c1f8333b12022-12-22T01:48:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.951976951976Thyroid and renal cancers: A bidirectional associationMaria Irene Bellini0Eleonora Lori1Flavio Forte2Augusto Lauro3Domenico Tripodi4Maria Ida Amabile5Vito Cantisani6Marzia Varanese7Iulia Catalina Ferent8Enke Baldini9Salvatore Ulisse10Vito D’Andrea11Daniele Pironi12Salvatore Sorrenti13Department of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Urology, M. G. Vannini Hospital, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Radiological, Anatomopathological and Oncological Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Surgical Sciences, Sapienza University of Rome, Rome, ItalyThere is a deep interrelation between the thyroid gland and the kidney parenchyma, with dysfunction of the first leading to significant changes in renal metabolism and vice versa. Given the recognition of cancer as a systemic disease, the raise of thyroid tumors and the common association of several malignancies, such as breast cancer, prostate cancer, colorectal cancer, and other, with an increased risk of kidney disease, public health alert for these conditions is warranted. A systematic review of the current evidence on the bidirectional relationship between thyroid and renal cancers was conducted including 18 studies, highlighting patient’s characteristics, histology, time for secondary malignancy to develop from the first diagnosis, treatment, and follow-up. A total of 776 patients were identified; median age was 64 years (range: 7–76 years). Obesity and family history were identified as the most common risk factors, and genetic susceptibility was suggested with a potential strong association with Cowden syndrome. Controversy on chemo and radiotherapy effects was found, as not all patients were previously exposed to these treatments. Men were more likely to develop kidney cancer after a primary thyroid malignancy, with 423/776 (54%) experiencing renal disease secondarily. Median time after the first malignancy was 5.2 years (range: 0–20 years). With the advancement of current oncological therapy, the prognosis for thyroid cancer patients has improved, although there has been a corresponding rise in the incidence of multiple secondary malignancy within the same population, particularly concerning the kidney. Surgery can achieve disease-free survival, if surveillance follow-up allows for an early localized form, where radical treatment is recommended.https://www.frontiersin.org/articles/10.3389/fonc.2022.951976/fullthyroid cancerrenal cancermultiple cancercancer surveillance and screeningcancer risk |
| spellingShingle | Maria Irene Bellini Eleonora Lori Flavio Forte Augusto Lauro Domenico Tripodi Maria Ida Amabile Vito Cantisani Marzia Varanese Iulia Catalina Ferent Enke Baldini Salvatore Ulisse Vito D’Andrea Daniele Pironi Salvatore Sorrenti Thyroid and renal cancers: A bidirectional association Frontiers in Oncology thyroid cancer renal cancer multiple cancer cancer surveillance and screening cancer risk |
| title | Thyroid and renal cancers: A bidirectional association |
| title_full | Thyroid and renal cancers: A bidirectional association |
| title_fullStr | Thyroid and renal cancers: A bidirectional association |
| title_full_unstemmed | Thyroid and renal cancers: A bidirectional association |
| title_short | Thyroid and renal cancers: A bidirectional association |
| title_sort | thyroid and renal cancers a bidirectional association |
| topic | thyroid cancer renal cancer multiple cancer cancer surveillance and screening cancer risk |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.951976/full |
| work_keys_str_mv | AT mariairenebellini thyroidandrenalcancersabidirectionalassociation AT eleonoralori thyroidandrenalcancersabidirectionalassociation AT flavioforte thyroidandrenalcancersabidirectionalassociation AT augustolauro thyroidandrenalcancersabidirectionalassociation AT domenicotripodi thyroidandrenalcancersabidirectionalassociation AT mariaidaamabile thyroidandrenalcancersabidirectionalassociation AT vitocantisani thyroidandrenalcancersabidirectionalassociation AT marziavaranese thyroidandrenalcancersabidirectionalassociation AT iuliacatalinaferent thyroidandrenalcancersabidirectionalassociation AT enkebaldini thyroidandrenalcancersabidirectionalassociation AT salvatoreulisse thyroidandrenalcancersabidirectionalassociation AT vitodandrea thyroidandrenalcancersabidirectionalassociation AT danielepironi thyroidandrenalcancersabidirectionalassociation AT salvatoresorrenti thyroidandrenalcancersabidirectionalassociation |