Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules
Heparin has been extensively studied as a safe medicine and biomolecule over the past few decades. Heparin derivatives, including low-molecular-weight heparins (LMWH) and heparin pentasaccharide, are effective anticoagulants currently used in clinical settings. They have also been studied as functio...
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| Format: | Article |
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MDPI AG
2021-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/19/10524 |
| _version_ | 1797516273860476928 |
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| author | Nipa Banik Seong-Bin Yang Tae-Bong Kang Ji-Hong Lim Jooho Park |
| author_facet | Nipa Banik Seong-Bin Yang Tae-Bong Kang Ji-Hong Lim Jooho Park |
| author_sort | Nipa Banik |
| collection | DOAJ |
| description | Heparin has been extensively studied as a safe medicine and biomolecule over the past few decades. Heparin derivatives, including low-molecular-weight heparins (LMWH) and heparin pentasaccharide, are effective anticoagulants currently used in clinical settings. They have also been studied as functional biomolecules or biomaterials for various therapeutic uses to treat diseases. Heparin, which has a similar molecular structure to heparan sulfate, can be used as a remarkable biomedicine due to its uniquely high safety and biocompatibility. In particular, it has recently drawn attention for use in drug-delivery systems, biomaterial-based tissue engineering, nanoformulations, and new drug-development systems through molecular formulas. A variety of new heparin-based biomolecules and conjugates have been developed in recent years and are currently being evaluated for use in clinical applications. This article reviews heparin derivatives recently studied in the field of drug development for the treatment of various diseases. |
| first_indexed | 2024-03-10T06:59:55Z |
| format | Article |
| id | doaj.art-7ae4cc9572a14ce2b139941f80951b03 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:59:55Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7ae4cc9572a14ce2b139941f80951b032023-11-22T16:11:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-0122191052410.3390/ijms221910524Heparin and Its Derivatives: Challenges and Advances in Therapeutic BiomoleculesNipa Banik0Seong-Bin Yang1Tae-Bong Kang2Ji-Hong Lim3Jooho Park4Department of Integrated Biosciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, KoreaDepartment of Integrated Biosciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, KoreaDepartment of Integrated Biosciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, KoreaDepartment of Integrated Biosciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, KoreaDepartment of Integrated Biosciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, KoreaHeparin has been extensively studied as a safe medicine and biomolecule over the past few decades. Heparin derivatives, including low-molecular-weight heparins (LMWH) and heparin pentasaccharide, are effective anticoagulants currently used in clinical settings. They have also been studied as functional biomolecules or biomaterials for various therapeutic uses to treat diseases. Heparin, which has a similar molecular structure to heparan sulfate, can be used as a remarkable biomedicine due to its uniquely high safety and biocompatibility. In particular, it has recently drawn attention for use in drug-delivery systems, biomaterial-based tissue engineering, nanoformulations, and new drug-development systems through molecular formulas. A variety of new heparin-based biomolecules and conjugates have been developed in recent years and are currently being evaluated for use in clinical applications. This article reviews heparin derivatives recently studied in the field of drug development for the treatment of various diseases.https://www.mdpi.com/1422-0067/22/19/10524heparinheparin derivativepolysaccharideanti-cancer effectbioconjugate |
| spellingShingle | Nipa Banik Seong-Bin Yang Tae-Bong Kang Ji-Hong Lim Jooho Park Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules International Journal of Molecular Sciences heparin heparin derivative polysaccharide anti-cancer effect bioconjugate |
| title | Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules |
| title_full | Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules |
| title_fullStr | Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules |
| title_full_unstemmed | Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules |
| title_short | Heparin and Its Derivatives: Challenges and Advances in Therapeutic Biomolecules |
| title_sort | heparin and its derivatives challenges and advances in therapeutic biomolecules |
| topic | heparin heparin derivative polysaccharide anti-cancer effect bioconjugate |
| url | https://www.mdpi.com/1422-0067/22/19/10524 |
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