Malaria’s molecular dance: Mechanism, therapies, and emerging insights
Malaria, caused by Plasmodium parasites and transmitted through Anopheles mosquitoes, remains a formidable global health challenge. This abstract provides an overview of the intricate molecular mechanisms underlying malaria pathogenesis, explores current therapeutic approaches, and highlights emergi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pensoft Publishers
2024-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/117145/download/pdf/ |
| _version_ | 1797289333340766208 |
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| author | Nabila Ananda Athaya Sabina Ulfa Rahmadani Ali Syahrizal Nabillah Deskya Sinta Maria Muhammad Riza Lusi Rahmadia Anni Holila Dwi Putri Kevin Gabriel Ratna Sari Zai Mega Carensia Princella Halim Naomi Regina Dinda Rizka Aulia Syahfitri Tessa Rotua Maria Belen Fahmy Nanda Rizzanda Pramuditya Khairunnisa Khairunnisa Emil Salim Fahrul Nurkolis Chindy Umaya Rony Abdi Syahputra |
| author_facet | Nabila Ananda Athaya Sabina Ulfa Rahmadani Ali Syahrizal Nabillah Deskya Sinta Maria Muhammad Riza Lusi Rahmadia Anni Holila Dwi Putri Kevin Gabriel Ratna Sari Zai Mega Carensia Princella Halim Naomi Regina Dinda Rizka Aulia Syahfitri Tessa Rotua Maria Belen Fahmy Nanda Rizzanda Pramuditya Khairunnisa Khairunnisa Emil Salim Fahrul Nurkolis Chindy Umaya Rony Abdi Syahputra |
| author_sort | Nabila Ananda |
| collection | DOAJ |
| description | Malaria, caused by Plasmodium parasites and transmitted through Anopheles mosquitoes, remains a formidable global health challenge. This abstract provides an overview of the intricate molecular mechanisms underlying malaria pathogenesis, explores current therapeutic approaches, and highlights emerging insights that may shape future strategies for malaria control. The intricate dance between Plasmodium parasites and their human hosts begins with the mosquito’s bite, leading to the invasion of erythrocytes by Plasmodium species. We delve into the molecular mechanisms governing parasite entry and subsequent replication within host cells, shedding light on key factors such as erythrocyte surface receptors and parasite-encoded proteins critical to invasion and survival. While malaria treatment has relied heavily on antimalarial drugs, the emergence of drug resistance necessitates ongoing exploration of novel therapeutic strategies. This abstract reviews current antimalarial drug classes, their mechanisms of action, and the challenges posed by drug resistance. We also highlight promising drug candidates and innovative approaches in the pipeline, including the use of advanced molecular techniques and immunotherapies. Emerging insights from genomics, proteomics, and transcriptomics have deepened our understanding of Plasmodium biology and host-parasite interactions. We discuss the potential of these omics approaches in identifying new drug targets, understanding drug resistance mechanisms, and developing vaccines. Additionally, we examine the role of human genetics in influencing susceptibility to malaria and response to treatment. Vector control remains a critical component of malaria prevention. We touch upon emerging strategies, such as genetically modified mosquitoes and novel insecticides, in the context of integrated vector management programs. Finally, we emphasize the importance of a multifaceted approach to malaria control, combining advances in molecular biology, drug development, vector control, and public health interventions. |
| first_indexed | 2024-03-07T19:03:26Z |
| format | Article |
| id | doaj.art-7ae711d1ffb74681aec3e899a4e1980a |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-03-07T19:03:26Z |
| publishDate | 2024-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-7ae711d1ffb74681aec3e899a4e1980a2024-03-01T10:41:50ZengPensoft PublishersPharmacia2603-557X2024-02-017111210.3897/pharmacia.71.e117145117145Malaria’s molecular dance: Mechanism, therapies, and emerging insightsNabila Ananda0Athaya Sabina1Ulfa Rahmadani2Ali Syahrizal3Nabillah Deskya4Sinta Maria5Muhammad Riza6Lusi Rahmadia7Anni Holila8Dwi Putri9Kevin Gabriel10Ratna Sari Zai11Mega Carensia12Princella Halim13Naomi Regina14Dinda Rizka15Aulia Syahfitri16Tessa Rotua17Maria Belen18Fahmy Nanda19Rizzanda Pramuditya20Khairunnisa Khairunnisa21Emil Salim22Fahrul Nurkolis23Chindy Umaya24Rony Abdi Syahputra25Universitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraUniversitas Sumatera UtaraState Islamic University of Sunan KalijagaUniversitas Sumatera UtaraUniversitas Sumatera UtaraMalaria, caused by Plasmodium parasites and transmitted through Anopheles mosquitoes, remains a formidable global health challenge. This abstract provides an overview of the intricate molecular mechanisms underlying malaria pathogenesis, explores current therapeutic approaches, and highlights emerging insights that may shape future strategies for malaria control. The intricate dance between Plasmodium parasites and their human hosts begins with the mosquito’s bite, leading to the invasion of erythrocytes by Plasmodium species. We delve into the molecular mechanisms governing parasite entry and subsequent replication within host cells, shedding light on key factors such as erythrocyte surface receptors and parasite-encoded proteins critical to invasion and survival. While malaria treatment has relied heavily on antimalarial drugs, the emergence of drug resistance necessitates ongoing exploration of novel therapeutic strategies. This abstract reviews current antimalarial drug classes, their mechanisms of action, and the challenges posed by drug resistance. We also highlight promising drug candidates and innovative approaches in the pipeline, including the use of advanced molecular techniques and immunotherapies. Emerging insights from genomics, proteomics, and transcriptomics have deepened our understanding of Plasmodium biology and host-parasite interactions. We discuss the potential of these omics approaches in identifying new drug targets, understanding drug resistance mechanisms, and developing vaccines. Additionally, we examine the role of human genetics in influencing susceptibility to malaria and response to treatment. Vector control remains a critical component of malaria prevention. We touch upon emerging strategies, such as genetically modified mosquitoes and novel insecticides, in the context of integrated vector management programs. Finally, we emphasize the importance of a multifaceted approach to malaria control, combining advances in molecular biology, drug development, vector control, and public health interventions.https://pharmacia.pensoft.net/article/117145/download/pdf/ |
| spellingShingle | Nabila Ananda Athaya Sabina Ulfa Rahmadani Ali Syahrizal Nabillah Deskya Sinta Maria Muhammad Riza Lusi Rahmadia Anni Holila Dwi Putri Kevin Gabriel Ratna Sari Zai Mega Carensia Princella Halim Naomi Regina Dinda Rizka Aulia Syahfitri Tessa Rotua Maria Belen Fahmy Nanda Rizzanda Pramuditya Khairunnisa Khairunnisa Emil Salim Fahrul Nurkolis Chindy Umaya Rony Abdi Syahputra Malaria’s molecular dance: Mechanism, therapies, and emerging insights Pharmacia |
| title | Malaria’s molecular dance: Mechanism, therapies, and emerging insights |
| title_full | Malaria’s molecular dance: Mechanism, therapies, and emerging insights |
| title_fullStr | Malaria’s molecular dance: Mechanism, therapies, and emerging insights |
| title_full_unstemmed | Malaria’s molecular dance: Mechanism, therapies, and emerging insights |
| title_short | Malaria’s molecular dance: Mechanism, therapies, and emerging insights |
| title_sort | malaria s molecular dance mechanism therapies and emerging insights |
| url | https://pharmacia.pensoft.net/article/117145/download/pdf/ |
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