Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
Hematology: Preserving a stable home for stem cells Steady production of immune and blood cells depends on a signaling protein that helps maintain stable stem cell populations within the bone marrow. Hematopoietic stem cells (HSCs), which give rise to blood cells, reside within a supportive “niche”...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-07-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-0477-y |
| _version_ | 1818655636195377152 |
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| author | Seon-Yeong Jeong Jungmook Lyu Jin-A Kim Il-Hoan Oh |
| author_facet | Seon-Yeong Jeong Jungmook Lyu Jin-A Kim Il-Hoan Oh |
| author_sort | Seon-Yeong Jeong |
| collection | DOAJ |
| description | Hematology: Preserving a stable home for stem cells Steady production of immune and blood cells depends on a signaling protein that helps maintain stable stem cell populations within the bone marrow. Hematopoietic stem cells (HSCs), which give rise to blood cells, reside within a supportive “niche” surrounded by mesenchymal stromal cells (MSCs), with extensive communication between the two populations. Researchers led by Il-Hoan Oh at The Catholic University of Korea, Seoul, have now identified a mechanism that MSCs employ to stabilize the niche environment through fine-tuning the signaling intensity of Wnt. Oh and colleagues focused on a signaling pathway that controls the undifferentiated state of HSCs, and showed that these signals are specifically modulated by an MSC protein known as Ryk. Without Ryk, MSCs can no longer promote HSC proliferation. However, when these signals are excessively strong, Ryk helps suppress proliferation to keep HSC numbers under control. |
| first_indexed | 2024-12-17T03:12:50Z |
| format | Article |
| id | doaj.art-7aeb783cd4e648caa33e6d0c8c8b4774 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-17T03:12:50Z |
| publishDate | 2020-07-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-7aeb783cd4e648caa33e6d0c8c8b47742022-12-21T22:05:47ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-07-015271140115110.1038/s12276-020-0477-yRyk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signalingSeon-Yeong Jeong0Jungmook Lyu1Jin-A Kim2Il-Hoan Oh3Department of Medical Lifescience, The Catholic University of Korea, College of MedicineMyung-Gok Eye Research Institute, Department of Medical Science, Konyang UniversityDepartment of Medical Lifescience, The Catholic University of Korea, College of MedicineDepartment of Medical Lifescience, The Catholic University of Korea, College of MedicineHematology: Preserving a stable home for stem cells Steady production of immune and blood cells depends on a signaling protein that helps maintain stable stem cell populations within the bone marrow. Hematopoietic stem cells (HSCs), which give rise to blood cells, reside within a supportive “niche” surrounded by mesenchymal stromal cells (MSCs), with extensive communication between the two populations. Researchers led by Il-Hoan Oh at The Catholic University of Korea, Seoul, have now identified a mechanism that MSCs employ to stabilize the niche environment through fine-tuning the signaling intensity of Wnt. Oh and colleagues focused on a signaling pathway that controls the undifferentiated state of HSCs, and showed that these signals are specifically modulated by an MSC protein known as Ryk. Without Ryk, MSCs can no longer promote HSC proliferation. However, when these signals are excessively strong, Ryk helps suppress proliferation to keep HSC numbers under control.https://doi.org/10.1038/s12276-020-0477-y |
| spellingShingle | Seon-Yeong Jeong Jungmook Lyu Jin-A Kim Il-Hoan Oh Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling Experimental and Molecular Medicine |
| title | Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling |
| title_full | Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling |
| title_fullStr | Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling |
| title_full_unstemmed | Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling |
| title_short | Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling |
| title_sort | ryk modulates the niche activity of mesenchymal stromal cells by fine tuning canonical wnt signaling |
| url | https://doi.org/10.1038/s12276-020-0477-y |
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