Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives
One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and o...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/11/10/2502 |
| _version_ | 1827678966568189952 |
|---|---|
| author | Anna S. Vikulina Jack Campbell |
| author_facet | Anna S. Vikulina Jack Campbell |
| author_sort | Anna S. Vikulina |
| collection | DOAJ |
| description | One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section. |
| first_indexed | 2024-03-10T06:20:11Z |
| format | Article |
| id | doaj.art-7aebb45f246a4ed6aaca426afbee1766 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T06:20:11Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-7aebb45f246a4ed6aaca426afbee17662023-11-22T19:22:16ZengMDPI AGNanomaterials2079-49912021-09-011110250210.3390/nano11102502Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and PerspectivesAnna S. Vikulina0Jack Campbell1Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg, 1, 14476 Potsdam, GermanySchool of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UKOne of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.https://www.mdpi.com/2079-4991/11/10/2502polyelectrolyte multilayersencapsulationcalcium carbonatedrug deliveryshrinkage |
| spellingShingle | Anna S. Vikulina Jack Campbell Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives Nanomaterials polyelectrolyte multilayers encapsulation calcium carbonate drug delivery shrinkage |
| title | Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives |
| title_full | Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives |
| title_fullStr | Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives |
| title_full_unstemmed | Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives |
| title_short | Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives |
| title_sort | biopolymer based multilayer capsules and beads made via templating advantages hurdles and perspectives |
| topic | polyelectrolyte multilayers encapsulation calcium carbonate drug delivery shrinkage |
| url | https://www.mdpi.com/2079-4991/11/10/2502 |
| work_keys_str_mv | AT annasvikulina biopolymerbasedmultilayercapsulesandbeadsmadeviatemplatingadvantageshurdlesandperspectives AT jackcampbell biopolymerbasedmultilayercapsulesandbeadsmadeviatemplatingadvantageshurdlesandperspectives |