Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment
The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic relevance of SUCNR1 and its association with tumor immune infiltrates and micro...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/24/6064 |
| _version_ | 1797461086828494848 |
|---|---|
| author | Rania Najm Mahmood Yaseen Hachim Richard K. Kandasamy |
| author_facet | Rania Najm Mahmood Yaseen Hachim Richard K. Kandasamy |
| author_sort | Rania Najm |
| collection | DOAJ |
| description | The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic relevance of SUCNR1 and its association with tumor immune infiltrates and microbiota in renal cell carcinoma (RCC). Herein, publicly available platforms including Human Protein Atlas, cBioPortal, TIMER2.0, and TISIDB were utilized to depict a divergent implication of SUCNR1 in the immune microenvironment of clear cell RCC (KIRC) and papillary RCC (KIRP); the two major subtypes of RCC. Our results showed that the SUCNR1 expression level was augmented in RCC compared to other solid cancers, yet with opposite survival rate predictions in RCC subtypes. Consequently, a higher expression level of SUCNR1 was associated with a good disease-specific survival rate (<i>p</i> = 5.797 × 10<sup>−5</sup>) in KIRC patients albeit a poor prognostic prediction in KIRP patients (<i>p</i> = 1.9282 × 10<sup>−3</sup>). Intriguingly, SUCNR1 was mainly correlated to immunomodulators and diverse immune infiltrates in KIRP. Additionally, the SUCNR1 was mostly associated with a repertoire of microbes including beneficial bacteria that likely influenced a better disease-specific survival rate in KIRC. Our findings illustrate a significant novel subtype-specific role of SUCNR1 in RCC which potentially modulates tumor immune infiltration and microbiome signature, hence altering the prognosis of cancer patients. |
| first_indexed | 2024-03-09T17:14:25Z |
| format | Article |
| id | doaj.art-7aee6db7be95435cb23a56e61de2c139 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:14:25Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7aee6db7be95435cb23a56e61de2c1392023-11-24T13:45:33ZengMDPI AGCancers2072-66942022-12-011424606410.3390/cancers14246064Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma MicroenvironmentRania Najm0Mahmood Yaseen Hachim1Richard K. Kandasamy2College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesCollege of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab EmiratesCentre of Molecular Inflammation Research (CEMIR), Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, 7491 Trondheim, NorwayThe succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic relevance of SUCNR1 and its association with tumor immune infiltrates and microbiota in renal cell carcinoma (RCC). Herein, publicly available platforms including Human Protein Atlas, cBioPortal, TIMER2.0, and TISIDB were utilized to depict a divergent implication of SUCNR1 in the immune microenvironment of clear cell RCC (KIRC) and papillary RCC (KIRP); the two major subtypes of RCC. Our results showed that the SUCNR1 expression level was augmented in RCC compared to other solid cancers, yet with opposite survival rate predictions in RCC subtypes. Consequently, a higher expression level of SUCNR1 was associated with a good disease-specific survival rate (<i>p</i> = 5.797 × 10<sup>−5</sup>) in KIRC patients albeit a poor prognostic prediction in KIRP patients (<i>p</i> = 1.9282 × 10<sup>−3</sup>). Intriguingly, SUCNR1 was mainly correlated to immunomodulators and diverse immune infiltrates in KIRP. Additionally, the SUCNR1 was mostly associated with a repertoire of microbes including beneficial bacteria that likely influenced a better disease-specific survival rate in KIRC. Our findings illustrate a significant novel subtype-specific role of SUCNR1 in RCC which potentially modulates tumor immune infiltration and microbiome signature, hence altering the prognosis of cancer patients.https://www.mdpi.com/2072-6694/14/24/6064succinate receptorrenal cell carcinomaKIRCKIRPtumor immune infiltratesimmunomodulators |
| spellingShingle | Rania Najm Mahmood Yaseen Hachim Richard K. Kandasamy Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment Cancers succinate receptor renal cell carcinoma KIRC KIRP tumor immune infiltrates immunomodulators |
| title | Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment |
| title_full | Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment |
| title_fullStr | Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment |
| title_full_unstemmed | Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment |
| title_short | Divulging a Pleiotropic Role of Succinate Receptor <i>SUCNR1</i> in Renal Cell Carcinoma Microenvironment |
| title_sort | divulging a pleiotropic role of succinate receptor i sucnr1 i in renal cell carcinoma microenvironment |
| topic | succinate receptor renal cell carcinoma KIRC KIRP tumor immune infiltrates immunomodulators |
| url | https://www.mdpi.com/2072-6694/14/24/6064 |
| work_keys_str_mv | AT ranianajm divulgingapleiotropicroleofsuccinatereceptorisucnr1iinrenalcellcarcinomamicroenvironment AT mahmoodyaseenhachim divulgingapleiotropicroleofsuccinatereceptorisucnr1iinrenalcellcarcinomamicroenvironment AT richardkkandasamy divulgingapleiotropicroleofsuccinatereceptorisucnr1iinrenalcellcarcinomamicroenvironment |