Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects
Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are used to deliver different kinds of therapeutics (e.g., small molecules,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095809923002102 |
| _version_ | 1797326303554174976 |
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| author | Tingting Peng Yangyan Chen Wanshan Hu Yao Huang Minmin Zhang Chao Lu Xin Pan Chuanbin Wu |
| author_facet | Tingting Peng Yangyan Chen Wanshan Hu Yao Huang Minmin Zhang Chao Lu Xin Pan Chuanbin Wu |
| author_sort | Tingting Peng |
| collection | DOAJ |
| description | Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are used to deliver different kinds of therapeutics (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) for treating various skin disorders, including superficial tumors, wounds, skin infections, inflammatory skin diseases, and abnormal skin appearance. The therapeutic efficacy of MNs can be improved by integrating the advantages of multiple therapeutics to perform combination therapy. Through careful designing, MNs can be further modified with biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermal delivery efficiency for robust therapeutic outcomes. Some studies have proposed the use of drug-free MNs as a promising mechanotherapeutic strategy to promote wound healing, scar removal, and hair regeneration via a mechanical communication pathway. Although MNs have several advantages, the practical application of MNs suffers from problems related to industrial manufacture and clinical evaluation, making it difficult for clinical translation. In this study, we summarized the various applications, emerging challenges, and developmental prospects of MNs in skin disorders to provide information on ways to advance clinical translation. |
| first_indexed | 2024-03-08T06:21:25Z |
| format | Article |
| id | doaj.art-7aef5c7de6c54cc8bb0ea76d9e2edde9 |
| institution | Directory Open Access Journal |
| issn | 2095-8099 |
| language | English |
| last_indexed | 2024-03-08T06:21:25Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Engineering |
| spelling | doaj.art-7aef5c7de6c54cc8bb0ea76d9e2edde92024-02-04T04:44:22ZengElsevierEngineering2095-80992023-11-0130170189Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and ProspectsTingting Peng0Yangyan Chen1Wanshan Hu2Yao Huang3Minmin Zhang4Chao Lu5Xin Pan6Chuanbin Wu7International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education of the People’s Republic of China, College of Pharmacy, Jinan University, Guangzhou 511436, ChinaSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education of the People’s Republic of China, College of Pharmacy, Jinan University, Guangzhou 511436, ChinaFaculty of Pharmacy, University of Helsinki, Helsinki 00014, FinlandSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, ChinaInternational Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education of the People’s Republic of China, College of Pharmacy, Jinan University, Guangzhou 511436, China; Corresponding authors.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Corresponding authors.International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education of the People’s Republic of China, College of Pharmacy, Jinan University, Guangzhou 511436, China; Corresponding authors.Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy while having minimum side effects. MNs are used to deliver different kinds of therapeutics (e.g., small molecules, macromolecules, nanomedicines, living cells, bacteria, and exosomes) for treating various skin disorders, including superficial tumors, wounds, skin infections, inflammatory skin diseases, and abnormal skin appearance. The therapeutic efficacy of MNs can be improved by integrating the advantages of multiple therapeutics to perform combination therapy. Through careful designing, MNs can be further modified with biomimetic structures for the responsive drug release from internal and external stimuli and to enhance the transdermal delivery efficiency for robust therapeutic outcomes. Some studies have proposed the use of drug-free MNs as a promising mechanotherapeutic strategy to promote wound healing, scar removal, and hair regeneration via a mechanical communication pathway. Although MNs have several advantages, the practical application of MNs suffers from problems related to industrial manufacture and clinical evaluation, making it difficult for clinical translation. In this study, we summarized the various applications, emerging challenges, and developmental prospects of MNs in skin disorders to provide information on ways to advance clinical translation.http://www.sciencedirect.com/science/article/pii/S2095809923002102MicroneedlesTransdermal drug delivery systemSkin disordersTreatmentsChallengesProspects |
| spellingShingle | Tingting Peng Yangyan Chen Wanshan Hu Yao Huang Minmin Zhang Chao Lu Xin Pan Chuanbin Wu Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects Engineering Microneedles Transdermal drug delivery system Skin disorders Treatments Challenges Prospects |
| title | Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects |
| title_full | Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects |
| title_fullStr | Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects |
| title_full_unstemmed | Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects |
| title_short | Microneedles for Enhanced Topical Treatment of Skin Disorders: Applications, Challenges, and Prospects |
| title_sort | microneedles for enhanced topical treatment of skin disorders applications challenges and prospects |
| topic | Microneedles Transdermal drug delivery system Skin disorders Treatments Challenges Prospects |
| url | http://www.sciencedirect.com/science/article/pii/S2095809923002102 |
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