A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations
Synaptojanin1 (Synj1) is a phosphoinositide phosphatase, important in clathrin uncoating during endocytosis of presynaptic vesicles. It was identified as a potential drug target for Alzheimer’s disease, Down syndrome, and TBC1D24-associated epilepsy, while also loss-of-function mutations in Synj1 ar...
Main Authors: | Jone Paesmans, Ella Martin, Babette Deckers, Marjolijn Berghmans, Ritika Sethi, Yannick Loeys, Els Pardon, Jan Steyaert, Patrik Verstreken, Christian Galicia, Wim Versées |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/64922 |
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