Mechanobiological Feedback in Pulmonary Vascular Disease
Vascular stiffening in the pulmonary arterial bed is increasingly recognized as an early disease marker and contributor to right ventricular workload in pulmonary hypertension. Changes in pulmonary artery stiffness throughout the pulmonary vascular tree lead to physiologic alterations in pressure an...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2018.00951/full |
| _version_ | 1818191190790504448 |
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| author | Paul B. Dieffenbach Marcy Maracle Daniel J. Tschumperlin Laura E. Fredenburgh |
| author_facet | Paul B. Dieffenbach Marcy Maracle Daniel J. Tschumperlin Laura E. Fredenburgh |
| author_sort | Paul B. Dieffenbach |
| collection | DOAJ |
| description | Vascular stiffening in the pulmonary arterial bed is increasingly recognized as an early disease marker and contributor to right ventricular workload in pulmonary hypertension. Changes in pulmonary artery stiffness throughout the pulmonary vascular tree lead to physiologic alterations in pressure and flow characteristics that may contribute to disease progression. These findings have led to a greater focus on the potential contributions of extracellular matrix remodeling and mechanical signaling to pulmonary hypertension pathogenesis. Several recent studies have demonstrated that the cellular response to vascular stiffness includes upregulation of signaling pathways that precipitate further vascular remodeling, a process known as mechanobiological feedback. The extracellular matrix modifiers, mechanosensors, and mechanotransducers responsible for this process have become increasingly well-recognized. In this review, we discuss the impact of vascular stiffening on pulmonary hypertension morbidity and mortality, evidence in favor of mechanobiological feedback in pulmonary hypertension pathogenesis, and the major contributors to mechanical signaling in the pulmonary vasculature. |
| first_indexed | 2024-12-12T00:10:40Z |
| format | Article |
| id | doaj.art-7af31da7b63340d39df6c938730f15fc |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T00:10:40Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-7af31da7b63340d39df6c938730f15fc2022-12-22T00:44:59ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2018-07-01910.3389/fphys.2018.00951390750Mechanobiological Feedback in Pulmonary Vascular DiseasePaul B. Dieffenbach0Marcy Maracle1Daniel J. Tschumperlin2Laura E. Fredenburgh3Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United StatesSchulich School of Medicine and Dentistry, Western University, London, ON, CanadaDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN, United StatesDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United StatesVascular stiffening in the pulmonary arterial bed is increasingly recognized as an early disease marker and contributor to right ventricular workload in pulmonary hypertension. Changes in pulmonary artery stiffness throughout the pulmonary vascular tree lead to physiologic alterations in pressure and flow characteristics that may contribute to disease progression. These findings have led to a greater focus on the potential contributions of extracellular matrix remodeling and mechanical signaling to pulmonary hypertension pathogenesis. Several recent studies have demonstrated that the cellular response to vascular stiffness includes upregulation of signaling pathways that precipitate further vascular remodeling, a process known as mechanobiological feedback. The extracellular matrix modifiers, mechanosensors, and mechanotransducers responsible for this process have become increasingly well-recognized. In this review, we discuss the impact of vascular stiffening on pulmonary hypertension morbidity and mortality, evidence in favor of mechanobiological feedback in pulmonary hypertension pathogenesis, and the major contributors to mechanical signaling in the pulmonary vasculature.https://www.frontiersin.org/article/10.3389/fphys.2018.00951/fullvascular stiffnesspulmonary arterial stiffnesspulmonary hypertensionmechanotransductioncellular mechanosensorsYAP/TAZ |
| spellingShingle | Paul B. Dieffenbach Marcy Maracle Daniel J. Tschumperlin Laura E. Fredenburgh Mechanobiological Feedback in Pulmonary Vascular Disease Frontiers in Physiology vascular stiffness pulmonary arterial stiffness pulmonary hypertension mechanotransduction cellular mechanosensors YAP/TAZ |
| title | Mechanobiological Feedback in Pulmonary Vascular Disease |
| title_full | Mechanobiological Feedback in Pulmonary Vascular Disease |
| title_fullStr | Mechanobiological Feedback in Pulmonary Vascular Disease |
| title_full_unstemmed | Mechanobiological Feedback in Pulmonary Vascular Disease |
| title_short | Mechanobiological Feedback in Pulmonary Vascular Disease |
| title_sort | mechanobiological feedback in pulmonary vascular disease |
| topic | vascular stiffness pulmonary arterial stiffness pulmonary hypertension mechanotransduction cellular mechanosensors YAP/TAZ |
| url | https://www.frontiersin.org/article/10.3389/fphys.2018.00951/full |
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