Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection

Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection

ABSTRACT Symptoms of Clostridioides difficile infection (CDI) are attributed largely to two toxins, TcdA and TcdB. About 17–23% of C. difficile isolates produce binary toxin, which enhances C. difficile pathogenesis. Previously, we engineered the nontoxigenic C. difficile strain CCUG37785 (designate...

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Bibliographic Details
Main Authors: Shaohui Wang, Joshua Heuler, Ishani Wickramage, Xingmin Sun
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:Microbiology Spectrum
Subjects:
Clostridioides difficile infection (CDI)
nontoxigenic Clostridioides difficile (NTCD)
spores
therapeutics
microbial colonization
pathogenicity locus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01788-21

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