Translating advances in microbial bioproduction to sustainable biotechnology
Advances in synthetic biology have radically changed our ability to rewire microorganisms and significantly improved the scalable production of a vast array of drop-in biopolymers and biofuels. The success of a drop-in bioproduct is contingent on market competition with petrochemical analogues and w...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.968437/full |
| _version_ | 1798037124196335616 |
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| author | David N. Carruthers David N. Carruthers Taek Soon Lee Taek Soon Lee |
| author_facet | David N. Carruthers David N. Carruthers Taek Soon Lee Taek Soon Lee |
| author_sort | David N. Carruthers |
| collection | DOAJ |
| description | Advances in synthetic biology have radically changed our ability to rewire microorganisms and significantly improved the scalable production of a vast array of drop-in biopolymers and biofuels. The success of a drop-in bioproduct is contingent on market competition with petrochemical analogues and weighted upon relative economic and environmental metrics. While the quantification of comparative trade-offs is critical for accurate process-level decision making, the translation of industrial ecology to synthetic biology is often ambiguous and assessment accuracy has proven challenging. In this review, we explore strategies for evaluating industrial biotechnology through life cycle and techno-economic assessment, then contextualize how recent developments in synthetic biology have improved process viability by expanding feedstock availability and the productivity of microbes. By juxtaposing biological and industrial constraints, we highlight major obstacles between the disparate disciplines that hinder accurate process evaluation. The convergence of these disciplines is crucial in shifting towards carbon neutrality and a circular bioeconomy. |
| first_indexed | 2024-04-11T21:22:19Z |
| format | Article |
| id | doaj.art-7af48a8cd9504d31a21111c00c7aa9a9 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-11T21:22:19Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-7af48a8cd9504d31a21111c00c7aa9a92022-12-22T04:02:35ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-08-011010.3389/fbioe.2022.968437968437Translating advances in microbial bioproduction to sustainable biotechnologyDavid N. Carruthers0David N. Carruthers1Taek Soon Lee2Taek Soon Lee3Joint BioEnergy Institute, Emeryville, CA, United StatesBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United StatesJoint BioEnergy Institute, Emeryville, CA, United StatesBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, United StatesAdvances in synthetic biology have radically changed our ability to rewire microorganisms and significantly improved the scalable production of a vast array of drop-in biopolymers and biofuels. The success of a drop-in bioproduct is contingent on market competition with petrochemical analogues and weighted upon relative economic and environmental metrics. While the quantification of comparative trade-offs is critical for accurate process-level decision making, the translation of industrial ecology to synthetic biology is often ambiguous and assessment accuracy has proven challenging. In this review, we explore strategies for evaluating industrial biotechnology through life cycle and techno-economic assessment, then contextualize how recent developments in synthetic biology have improved process viability by expanding feedstock availability and the productivity of microbes. By juxtaposing biological and industrial constraints, we highlight major obstacles between the disparate disciplines that hinder accurate process evaluation. The convergence of these disciplines is crucial in shifting towards carbon neutrality and a circular bioeconomy.https://www.frontiersin.org/articles/10.3389/fbioe.2022.968437/fullsynthetic biologybioproductionlife cycle assessment (LCA)techno-economic assessment (TEA)bioeconomy |
| spellingShingle | David N. Carruthers David N. Carruthers Taek Soon Lee Taek Soon Lee Translating advances in microbial bioproduction to sustainable biotechnology Frontiers in Bioengineering and Biotechnology synthetic biology bioproduction life cycle assessment (LCA) techno-economic assessment (TEA) bioeconomy |
| title | Translating advances in microbial bioproduction to sustainable biotechnology |
| title_full | Translating advances in microbial bioproduction to sustainable biotechnology |
| title_fullStr | Translating advances in microbial bioproduction to sustainable biotechnology |
| title_full_unstemmed | Translating advances in microbial bioproduction to sustainable biotechnology |
| title_short | Translating advances in microbial bioproduction to sustainable biotechnology |
| title_sort | translating advances in microbial bioproduction to sustainable biotechnology |
| topic | synthetic biology bioproduction life cycle assessment (LCA) techno-economic assessment (TEA) bioeconomy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.968437/full |
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