Kunxian capsule alleviates podocyte injury and proteinuria by inactivating β-catenin in db/db mice

Kunxian capsule alleviates podocyte injury and proteinuria by inactivating β-catenin in db/db mice

BackgroundDiabetic kidney disease (DKD) remains the primary cause of end-stage renal disease (ESRD) globally, but treatment options are limited. Kunxian capsule (KXC) has been utilized for the treatment of autoimmune diseases and IgA nephropathy in China. However, its effect on DKD remains poorly in...

Full description

Bibliographic Details
Main Authors:	Bo Jin, Jing Liu, Yan Zhu, Jian Lu, Qingyan Zhang, Yan Liang, Qiuyuan Shao, Chunming Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Medicine
Subjects:	Kunxian capsule diabetic kidney disease podocyte β-Catenin epithelial-to-mesenchymal transition
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1213191/full

Similar Items

Long noncoding RNA MEG3 suppresses podocyte injury in diabetic nephropathy by inactivating Wnt/β-catenin signaling
by: Xiajing Che, et al.
Published: (2019-11-01)

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats
by: Xie L, et al.
Published: (2020-02-01)

Zuogui Wan ameliorates high glucose-induced podocyte apoptosis and improves diabetic nephropathy in db/db mice
by: Bingbing Zhu, et al.
Published: (2022-11-01)

Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice
by: Xiaoya Li, et al.
Published: (2023-10-01)

Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease
by: Le Gong, et al.
Published: (2023-12-01)

A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats
by: Yasunobu Iwata, et al.
Published: (2023-10-01)

suPAR and WT1 modify the adhesion of podocytes and are related to proteinuria in class IV lupus nephritis
by: Juan-José Bollain-y-Goytia, et al.
Published: (2023-12-01)

Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties
by: Elias A. Lianos, et al.
Published: (2023-08-01)

SGLT2 Inhibitor Empagliflozin and DPP4 Inhibitor Linagliptin Reactivate Glomerular Autophagy in <i>db/db</i> Mice, a Model of Type 2 Diabetes
by: Anton I. Korbut, et al.
Published: (2020-04-01)

Molecular and Cellular Events Mediating Glomerular Podocyte Dysfunction and Depletion in Diabetes Mellitus
by: Ram K Menon, et al.
Published: (2014-09-01)

Metformin Protects against Podocyte Injury in Diabetic Kidney Disease
by: Sanna Lehtonen
Published: (2020-12-01)

Quantifying Podocyte Number in a Small Sample Size of Glomeruli with CUBIC to Evaluate Podocyte Depletion of db/db Mice
by: Jiaoyu Shi, et al.
Published: (2023-01-01)

Sanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation
by: Wang L, et al.
Published: (2023-06-01)

Tangeretin Ameliorates Glucose-Induced Podocyte Injury through Blocking Epithelial to Mesenchymal Transition Caused by Oxidative Stress and Hypoxia
by: Min-Kyung Kang, et al.
Published: (2020-11-01)

Huaiqihuang may protect from proteinuria by resisting MPC5 podocyte damage via targeting p-ERK/CHOP pathway
by: Tingxia Li, et al.
Published: (2016-08-01)

New insights into the immune functions of podocytes: the role of complement
by: Valentina Bruno, et al.
Published: (2023-04-01)

Nonimmunologic targets of immunosuppressive agents in podocytes
by: Tae-Hyun Yoo, et al.
Published: (2015-06-01)

Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism
by: Li Lin, et al.
Published: (2023-11-01)

Podocytes—The Most Vulnerable Renal Cells in Preeclampsia
by: Ewa Kwiatkowska, et al.
Published: (2020-07-01)

The Physiopathologic Roles of Calcium Signaling in Podocytes
by: Yu-Chi Tu, et al.
Published: (2023-10-01)

Paracrine Effects of Renal Proximal Tubular Epithelial Cells on Podocyte Injury under Hypoxic Conditions Are Mediated by Arginase-II and TGF-β1
by: Yiqiong Ma, et al.
Published: (2023-02-01)

Podocyte infolding glomerulopathy; current concepts
by: Azadeh Khayyat, et al.
Published: (2023-03-01)

Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy
by: Linlin Sun, et al.
Published: (2023-02-01)

Over-expression of APMAP alleviates glomerular podocyte injury in adriamycin nephropathy
by: WU Jingyi, FAN Wenjing, YAN Donghua
Published: (2023-12-01)

The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes
by: Chia-Jung Yu, et al.
Published: (2021-12-01)

Podocyte injury of diabetic nephropathy: Novel mechanism discovery and therapeutic prospects
by: Xiandeng Li, et al.
Published: (2023-12-01)

Podocyte Autophagy in Homeostasis and Disease
by: Qisheng Lin, et al.
Published: (2021-03-01)

Mogroside IIIE Alleviates High Glucose-Induced Inflammation, Oxidative Stress and Apoptosis of Podocytes by the Activation of AMPK/SIRT1 Signaling Pathway
by: Xue W, et al.
Published: (2020-10-01)

Role of Arginase-II in Podocyte Injury under Hypoxic Conditions
by: Zhilong Ren, et al.
Published: (2022-08-01)

Treatment of Membranous Nephropathy by Disulfiram through Inhibition of Podocyte Pyroptosis
by: Daoyuan Lv, et al.
Published: (2022-05-01)

Effects of High Glucose and Lipotoxicity on Diabetic Podocytes
by: Ran Nakamichi, et al.
Published: (2021-01-01)

Potential therapeutic effects of natural compounds targeting autophagy to alleviate podocyte injury in glomerular diseases
by: Tongtong Liu, et al.
Published: (2022-11-01)

Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish
by: Bridgette E. Drummond, et al.
Published: (2023-02-01)

CD73 Overexpression in Podocytes: A Novel Marker of Podocyte Injury in Human Kidney Disease
by: Zoran V. Popovic, et al.
Published: (2021-07-01)

Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice
by: Guillaume Ajalbert, et al.
Published: (2023-07-01)

Podocyte number and glomerulosclerosis indices are associated with the response to therapy for primary focal segmental glomerulosclerosis
by: Natasha de Zoysa, et al.
Published: (2024-03-01)

Podocyte-Related Mechanisms Underlying Survival Benefit of Long-Term Angiotensin Receptor Blocker
by: Xuejing Zhu, et al.
Published: (2022-05-01)

Engineering antioxidant ceria-zirconia nanomedicines for alleviating podocyte injury in rats with adriamycin-induced nephrotic syndrome
by: Lili Liu, et al.
Published: (2023-10-01)

Regulation of the Actin Cytoskeleton in Podocytes
by: Judith Blaine, et al.
Published: (2020-07-01)

PFKFB3 downregulation aggravates Angiotensin II-induced podocyte detachment
by: Xiaoxiao Huang, et al.
Published: (2023-12-01)