Glucocorticoid-Induced Ocular Hypertension and Glaucoma
Devon Hori Harvey,1,2 Chenna Kesavulu Sugali,1,2 Weiming Mao1– 5 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA; 2Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA; 3Department of Biochemistry & Molecu...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/glucocorticoid-induced-ocular-hypertension-and-glaucoma-peer-reviewed-fulltext-article-OPTH |
| _version_ | 1797303471912779776 |
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| author | Harvey DH Sugali CK Mao W |
| author_facet | Harvey DH Sugali CK Mao W |
| author_sort | Harvey DH |
| collection | DOAJ |
| description | Devon Hori Harvey,1,2 Chenna Kesavulu Sugali,1,2 Weiming Mao1– 5 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA; 2Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA; 3Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; 4Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA; 5Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USACorrespondence: Weiming Mao, Department of Ophthalmology, Indiana University School of Medicine, RM305v, 1160 W. Michigan St, Indianapolis, IN, 46202, USA, Tel +1 317 278 0801, Email weimmao@iu.eduAbstract: Glucocorticoid (GC) therapy is indicated in many diseases, including ocular diseases. An important side-effect of GC therapy is GC-induced ocular hypertension (GIOHT), which may cause irreversible blindness known as GC-induced glaucoma (GIG). Here, we reviewed the pathological changes that contribute to GIOHT including in the trabecular meshwork and Schlemm’s canal at cellular and molecular levels. We also discussed the clinical aspects of GIOHT/GIG including disease prevalence, risk factors, the type of GCs, the route of GC administration, and management strategies.Keywords: glucocorticoid, intraocular pressure, trabecular meshwork, aqueous humor outflow, mechanism, treatment |
| first_indexed | 2024-03-07T23:54:01Z |
| format | Article |
| id | doaj.art-7af810b22f444401839e51dc98011bda |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-03-07T23:54:01Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-7af810b22f444401839e51dc98011bda2024-02-18T16:42:54ZengDove Medical PressClinical Ophthalmology1177-54832024-02-01Volume 1848150590515Glucocorticoid-Induced Ocular Hypertension and GlaucomaHarvey DHSugali CKMao WDevon Hori Harvey,1,2 Chenna Kesavulu Sugali,1,2 Weiming Mao1– 5 1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA; 2Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA; 3Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; 4Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, USA; 5Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USACorrespondence: Weiming Mao, Department of Ophthalmology, Indiana University School of Medicine, RM305v, 1160 W. Michigan St, Indianapolis, IN, 46202, USA, Tel +1 317 278 0801, Email weimmao@iu.eduAbstract: Glucocorticoid (GC) therapy is indicated in many diseases, including ocular diseases. An important side-effect of GC therapy is GC-induced ocular hypertension (GIOHT), which may cause irreversible blindness known as GC-induced glaucoma (GIG). Here, we reviewed the pathological changes that contribute to GIOHT including in the trabecular meshwork and Schlemm’s canal at cellular and molecular levels. We also discussed the clinical aspects of GIOHT/GIG including disease prevalence, risk factors, the type of GCs, the route of GC administration, and management strategies.Keywords: glucocorticoid, intraocular pressure, trabecular meshwork, aqueous humor outflow, mechanism, treatmenthttps://www.dovepress.com/glucocorticoid-induced-ocular-hypertension-and-glaucoma-peer-reviewed-fulltext-article-OPTHglucocorticoidintraocular pressuretrabecular meshworkaqueous humor outflowmechanismtreatment |
| spellingShingle | Harvey DH Sugali CK Mao W Glucocorticoid-Induced Ocular Hypertension and Glaucoma Clinical Ophthalmology glucocorticoid intraocular pressure trabecular meshwork aqueous humor outflow mechanism treatment |
| title | Glucocorticoid-Induced Ocular Hypertension and Glaucoma |
| title_full | Glucocorticoid-Induced Ocular Hypertension and Glaucoma |
| title_fullStr | Glucocorticoid-Induced Ocular Hypertension and Glaucoma |
| title_full_unstemmed | Glucocorticoid-Induced Ocular Hypertension and Glaucoma |
| title_short | Glucocorticoid-Induced Ocular Hypertension and Glaucoma |
| title_sort | glucocorticoid induced ocular hypertension and glaucoma |
| topic | glucocorticoid intraocular pressure trabecular meshwork aqueous humor outflow mechanism treatment |
| url | https://www.dovepress.com/glucocorticoid-induced-ocular-hypertension-and-glaucoma-peer-reviewed-fulltext-article-OPTH |
| work_keys_str_mv | AT harveydh glucocorticoidinducedocularhypertensionandglaucoma AT sugalick glucocorticoidinducedocularhypertensionandglaucoma AT maow glucocorticoidinducedocularhypertensionandglaucoma |