An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo
Abstract Transparent ultrasound transducers (TUTs) can seamlessly integrate optical and ultrasound components, but acoustic impedance mismatch prohibits existing TUTs from being practical substitutes for conventional opaque ultrasound transducers. Here, we propose a transparent adhesive based on a s...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-45273-4 |
| _version_ | 1797274101118664704 |
|---|---|
| author | Seonghee Cho Minsu Kim Joongho Ahn Yeonggeun Kim Junha Lim Jeongwoo Park Hyung Ham Kim Won Jong Kim Chulhong Kim |
| author_facet | Seonghee Cho Minsu Kim Joongho Ahn Yeonggeun Kim Junha Lim Jeongwoo Park Hyung Ham Kim Won Jong Kim Chulhong Kim |
| author_sort | Seonghee Cho |
| collection | DOAJ |
| description | Abstract Transparent ultrasound transducers (TUTs) can seamlessly integrate optical and ultrasound components, but acoustic impedance mismatch prohibits existing TUTs from being practical substitutes for conventional opaque ultrasound transducers. Here, we propose a transparent adhesive based on a silicon dioxide-epoxy composite to fabricate matching and backing layers with acoustic impedances of 7.5 and 4–6 MRayl, respectively. By employing these layers, we develop an ultrasensitive, broadband TUT with 63% bandwidth at a single resonance frequency and high optical transparency ( > 80%), comparable to conventional opaque ultrasound transducers. Our TUT maximises both acoustic power and transfer efficiency with maximal spectrum flatness while minimising ringdowns. This enables high contrast and high-definition dual-modal ultrasound and photoacoustic imaging in live animals and humans. Both modalities reach an imaging depth of > 15 mm, with depth-to-resolution ratios exceeding 500 and 370, respectively. This development sets a new standard for TUTs, advancing the possibilities of sensor fusion. |
| first_indexed | 2024-03-07T14:53:33Z |
| format | Article |
| id | doaj.art-7af8be23c6434c9eade36a951ea6f564 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-07T14:53:33Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7af8be23c6434c9eade36a951ea6f5642024-03-05T19:33:14ZengNature PortfolioNature Communications2041-17232024-02-0115111510.1038/s41467-024-45273-4An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivoSeonghee Cho0Minsu Kim1Joongho Ahn2Yeonggeun Kim3Junha Lim4Jeongwoo Park5Hyung Ham Kim6Won Jong Kim7Chulhong Kim8Department of Electrical Engineering, Pohang University of Science and TechnologyMedical Device Innovation Center, Pohang University of Science and TechnologyMedical Device Innovation Center, Pohang University of Science and TechnologyMedical Device Innovation Center, Pohang University of Science and TechnologyDepartment of Chemistry, Pohang University of Science and TechnologyMedical Device Innovation Center, Pohang University of Science and TechnologyDepartment of Electrical Engineering, Pohang University of Science and TechnologyDepartment of Chemistry, Pohang University of Science and TechnologyDepartment of Electrical Engineering, Pohang University of Science and TechnologyAbstract Transparent ultrasound transducers (TUTs) can seamlessly integrate optical and ultrasound components, but acoustic impedance mismatch prohibits existing TUTs from being practical substitutes for conventional opaque ultrasound transducers. Here, we propose a transparent adhesive based on a silicon dioxide-epoxy composite to fabricate matching and backing layers with acoustic impedances of 7.5 and 4–6 MRayl, respectively. By employing these layers, we develop an ultrasensitive, broadband TUT with 63% bandwidth at a single resonance frequency and high optical transparency ( > 80%), comparable to conventional opaque ultrasound transducers. Our TUT maximises both acoustic power and transfer efficiency with maximal spectrum flatness while minimising ringdowns. This enables high contrast and high-definition dual-modal ultrasound and photoacoustic imaging in live animals and humans. Both modalities reach an imaging depth of > 15 mm, with depth-to-resolution ratios exceeding 500 and 370, respectively. This development sets a new standard for TUTs, advancing the possibilities of sensor fusion.https://doi.org/10.1038/s41467-024-45273-4 |
| spellingShingle | Seonghee Cho Minsu Kim Joongho Ahn Yeonggeun Kim Junha Lim Jeongwoo Park Hyung Ham Kim Won Jong Kim Chulhong Kim An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo Nature Communications |
| title | An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo |
| title_full | An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo |
| title_fullStr | An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo |
| title_full_unstemmed | An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo |
| title_short | An ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in-vivo |
| title_sort | ultrasensitive and broadband transparent ultrasound transducer for ultrasound and photoacoustic imaging in vivo |
| url | https://doi.org/10.1038/s41467-024-45273-4 |
| work_keys_str_mv | AT seongheecho anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT minsukim anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT joonghoahn anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT yeonggeunkim anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT junhalim anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT jeongwoopark anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT hyunghamkim anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT wonjongkim anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT chulhongkim anultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT seongheecho ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT minsukim ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT joonghoahn ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT yeonggeunkim ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT junhalim ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT jeongwoopark ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT hyunghamkim ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT wonjongkim ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo AT chulhongkim ultrasensitiveandbroadbandtransparentultrasoundtransducerforultrasoundandphotoacousticimaginginvivo |