1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity
1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-<i>a</i>]quinoxaline derivati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2020/1/M1113 |
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| author | Jean Guillon Solène Savrimoutou Sandra Rubio Stéphane Moreau Noël Pinaud Mathieu Marchivie Vanessa Desplat |
| author_facet | Jean Guillon Solène Savrimoutou Sandra Rubio Stéphane Moreau Noël Pinaud Mathieu Marchivie Vanessa Desplat |
| author_sort | Jean Guillon |
| collection | DOAJ |
| description | 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-<i>a</i>]quinoxaline derivative was achieved by FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells). |
| first_indexed | 2024-12-11T23:03:03Z |
| format | Article |
| id | doaj.art-7af8c00ab5ba45e4a462029a296aad95 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-12-11T23:03:03Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-7af8c00ab5ba45e4a462029a296aad952022-12-22T00:47:01ZengMDPI AGMolbank1422-85992020-01-0120201M111310.3390/M1113M11131-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic ActivityJean Guillon0Solène Savrimoutou1Sandra Rubio2Stéphane Moreau3Noël Pinaud4Mathieu Marchivie5Vanessa Desplat6University of Bordeaux, Faculty of Pharmacy, INSERM U1212 / UMR CNRS 5320, ARNA Laboratory, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, FranceUniversity of Bordeaux, Faculty of Pharmacy, INSERM U1212 / UMR CNRS 5320, ARNA Laboratory, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, FranceUniversity of Bordeaux, Faculty of Pharmacy, INSERM U1212 / UMR CNRS 5320, ARNA Laboratory, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, FranceUniversity of Bordeaux, Faculty of Pharmacy, INSERM U1212 / UMR CNRS 5320, ARNA Laboratory, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, FranceUniversity of Bordeaux, ISM—CNRS UMR 5255, F-33405 Talence CEDEX, FranceCNRS, University of Bordeaux, Bordeaux INP, ICMCB, UMR 5026, F-33600 Pessac, FranceUniversity of Bordeaux, Faculty of Pharmacy, INSERM U1035, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one has been successfully synthesized via a multi-step pathway starting from 2-nitroaniline. Structure characterization of this original pyrrolo[1,2-<i>a</i>]quinoxaline derivative was achieved by FT-IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, X-Ray and HRMS spectral analysis. This title compound shows interesting cytotoxic potential against several human leukemia cell lines (K562, HL60, and U937 cells).https://www.mdpi.com/1422-8599/2020/1/M1113pyrrolo[1,2-<i>a</i>]quinoxaline derivativeleukemiaantiproliferative activity |
| spellingShingle | Jean Guillon Solène Savrimoutou Sandra Rubio Stéphane Moreau Noël Pinaud Mathieu Marchivie Vanessa Desplat 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity Molbank pyrrolo[1,2-<i>a</i>]quinoxaline derivative leukemia antiproliferative activity |
| title | 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity |
| title_full | 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity |
| title_fullStr | 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity |
| title_full_unstemmed | 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity |
| title_short | 1-Phenyl-8-[[4-(pyrrolo[1,2-<i>a</i>]quinoxalin-4-yl)phenyl]methyl]-1,3,8-triazaspiro[4.5]decan-4-one: Synthesis, Crystal Structure and Anti-Leukemic Activity |
| title_sort | 1 phenyl 8 4 pyrrolo 1 2 i a i quinoxalin 4 yl phenyl methyl 1 3 8 triazaspiro 4 5 decan 4 one synthesis crystal structure and anti leukemic activity |
| topic | pyrrolo[1,2-<i>a</i>]quinoxaline derivative leukemia antiproliferative activity |
| url | https://www.mdpi.com/1422-8599/2020/1/M1113 |
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