Recapitulating the Vasculature Using Organ-On-Chip Technology
The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/7/1/17 |
| _version_ | 1797706657209253888 |
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| author | Andreas M.A.O. Pollet Jaap M.J. den Toonder |
| author_facet | Andreas M.A.O. Pollet Jaap M.J. den Toonder |
| author_sort | Andreas M.A.O. Pollet |
| collection | DOAJ |
| description | The development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the capability of recapitulating the in vivo vasculature differs greatly between them. The first part of this review discusses the biological background of the in vivo vasculature and all the associated processes. We then evaluate the biological relevance of different fabrication methods proposed for Vasculature-on-Chip, we indicate their possibilities and limitations, and we assess which fabrication methods are capable of recapitulating the intrinsic complexity of the vasculature. This review illustrates the complexity involved in developing in vitro vasculature and provides an overview of fabrication methods for Vasculature-on-Chip in relation to the biological relevance of such methods. |
| first_indexed | 2024-03-12T05:54:32Z |
| format | Article |
| id | doaj.art-7af911115ac949b789882b1d272946a3 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T05:54:32Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-7af911115ac949b789882b1d272946a32023-09-03T04:46:44ZengMDPI AGBioengineering2306-53542020-02-01711710.3390/bioengineering7010017bioengineering7010017Recapitulating the Vasculature Using Organ-On-Chip TechnologyAndreas M.A.O. Pollet0Jaap M.J. den Toonder1Microsystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The NetherlandsMicrosystems, Department of Mechanical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The NetherlandsThe development of Vasculature-on-Chip has progressed rapidly over the last decade and recently, a wealth of fabrication possibilities has emerged that can be used for engineering vessels on a chip. All these fabrication methods have their own advantages and disadvantages but, more importantly, the capability of recapitulating the in vivo vasculature differs greatly between them. The first part of this review discusses the biological background of the in vivo vasculature and all the associated processes. We then evaluate the biological relevance of different fabrication methods proposed for Vasculature-on-Chip, we indicate their possibilities and limitations, and we assess which fabrication methods are capable of recapitulating the intrinsic complexity of the vasculature. This review illustrates the complexity involved in developing in vitro vasculature and provides an overview of fabrication methods for Vasculature-on-Chip in relation to the biological relevance of such methods.https://www.mdpi.com/2306-5354/7/1/17vasculatureorgan-on-chipmicrofabricationmicrofluidicsangiogenesisvasculogenesis |
| spellingShingle | Andreas M.A.O. Pollet Jaap M.J. den Toonder Recapitulating the Vasculature Using Organ-On-Chip Technology Bioengineering vasculature organ-on-chip microfabrication microfluidics angiogenesis vasculogenesis |
| title | Recapitulating the Vasculature Using Organ-On-Chip Technology |
| title_full | Recapitulating the Vasculature Using Organ-On-Chip Technology |
| title_fullStr | Recapitulating the Vasculature Using Organ-On-Chip Technology |
| title_full_unstemmed | Recapitulating the Vasculature Using Organ-On-Chip Technology |
| title_short | Recapitulating the Vasculature Using Organ-On-Chip Technology |
| title_sort | recapitulating the vasculature using organ on chip technology |
| topic | vasculature organ-on-chip microfabrication microfluidics angiogenesis vasculogenesis |
| url | https://www.mdpi.com/2306-5354/7/1/17 |
| work_keys_str_mv | AT andreasmaopollet recapitulatingthevasculatureusingorganonchiptechnology AT jaapmjdentoonder recapitulatingthevasculatureusingorganonchiptechnology |