Systematic Evaluation of HILIC Stationary Phases for Global Metabolomics of Human Plasma

Systematic Evaluation of HILIC Stationary Phases for Global Metabolomics of Human Plasma

Polar hydrophilic metabolites have been identified as important actors in many biochemical pathways. Despite continuous improvement and refinement of hydrophilic interaction liquid chromatography (HILIC) platforms, its application in global polar metabolomics has been underutilized. In this study, w...

Full description

Bibliographic Details
Main Authors:	Farideh Hosseinkhani, Luojiao Huang, Anne-Charlotte Dubbelman, Faisa Guled, Amy C. Harms, Thomas Hankemeier
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Metabolites
Subjects:	HILIC untargeted metabolomics polar metabolites plasma metabolomics liquid chromatography
Online Access:	https://www.mdpi.com/2218-1989/12/2/165

Similar Items

Untargeted HILIC-MS-Based Metabolomics Approach to Evaluate Coffee Roasting Process: Contributing to an Integrated Metabolomics Multiplatform
by: Raquel Pérez-Míguez, et al.
Published: (2020-02-01)

Towards Standards for Human Fecal Sample Preparation in Targeted and Untargeted LC-HRMS Studies
by: Farideh Hosseinkhani, et al.
Published: (2021-06-01)

Mass spectrometry of the white adipose metabolome in a hibernating mammal reveals seasonal changes in alternate fuels and carnitine derivatives
by: Frazer I. Heinis, et al.
Published: (2023-06-01)

Combining Hydrophilic Interaction Chromatography (HILIC) and Isotope Tagging for Off-Line LC-NMR Applications in Metabolite Analysis
by: Daniel Raftery, et al.
Published: (2013-07-01)

Modelling of Hydrophilic Interaction Liquid Chromatography Stationary Phases Using Chemometric Approaches
by: Meritxell Navarro-Reig, et al.
Published: (2017-10-01)

Optimization Strategies for Mass Spectrometry-Based Untargeted Metabolomics Analysis of Small Polar Molecules in Human Plasma
by: Michał Kaczmarek, et al.
Published: (2023-08-01)

LC-MS investigated as a tool to study the metabolomic characteristics of cereal fermentation
by: Rishibha Gupta, et al.
Published: (2024-06-01)

Plasma and milk metabolomics in lactating sheep divergent for feed efficiency
by: Pablo G. Toral, et al.
Published: (2023-06-01)

Discovery of potential biomarkers for osteoporosis using LC/GC−MS metabolomic methods
by: Yahui Wu, et al.
Published: (2024-01-01)

<sup>1</sup>H NMR Metabolomics on Pigs’ Liver Exposed to Antibiotics Administration: An Explorative Study
by: Maria Pia Fabrile, et al.
Published: (2023-11-01)

Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas
by: Tanja Gumpenberger, et al.
Published: (2021-02-01)

Dataset on metabolome dimorphism in different organs of mature Palaemon serratus prawn
by: Benjamin Marie, et al.
Published: (2023-06-01)

Untargeted plasma metabolome identifies biomarkers in patients with extracranial arteriovenous malformations
by: Xueqiang Fan, et al.
Published: (2023-09-01)

Untargeted Metabolomics Identifies a Novel Panel of Markers for Autologous Blood Transfusion
by: Amna Al-Nesf, et al.
Published: (2022-05-01)

Silica Monolithic Capillary Columns for Hilic Separations
by: Moravcová Dana, et al.
Published: (2018-07-01)

Identification of Canine Pyometra-Associated Metabolites Using Untargeted Metabolomics
by: Hui-Hua Zheng, et al.
Published: (2022-11-01)

A Comprehensive Workflow of Mass Spectrometry-Based Untargeted Metabolomics in Cancer Metabolic Biomarker Discovery Using Human Plasma and Urine
by: Jianwen She, et al.
Published: (2013-09-01)

Comparison of Online Comprehensive HILIC × RP and RP × RP with Trapping Modulation Coupled to Mass Spectrometry for Microalgae Peptidomics
by: Eduardo Sommella, et al.
Published: (2020-04-01)

Untargeted serum metabolomics and tryptophan metabolism profiling in type 2 diabetic patients with diabetic glomerulopathy
by: Fanliang Zhang, et al.
Published: (2021-01-01)

LC-HRMS/MS-Based Metabolomics Approaches Applied to the Detection of Antifungal Compounds and a Metabolic Dynamic Assessment of Orchidaceae
by: Gesiane S. Lima, et al.
Published: (2022-11-01)

Untargeted Metabolomics to Explore the Bacteria Exo-Metabolome Related to Plant Biostimulants
by: Carlos J. García, et al.
Published: (2022-08-01)

OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
by: RALUCA TAMPU, et al.
Published: (2017-03-01)

OPTIMIZATION OF NEUROTRANSMITTERS SEPARATION UNDER HILIC CONDITIONS
by: RALUCA TAMPU, et al.
Published: (2017-03-01)

Metabolite Profiles of the Cerebrospinal Fluid in Neurosyphilis Patients Determined by Untargeted Metabolomics Analysis
by: Li-Li Liu, et al.
Published: (2019-02-01)

Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology
by: Wen Luo, et al.
Published: (2021-04-01)

Hydrophilic Interaction Liquid Chromatography–Hydrogen/Deuterium Exchange–Mass Spectrometry (HILIC-HDX-MS) for Untargeted Metabolomics
by: Tomas Cajka, et al.
Published: (2024-03-01)

HILIC-MS for Untargeted Profiling of the Free Glycation Product Diversity
by: Yingfei Yan, et al.
Published: (2022-11-01)

Exploring Chemical Markers Related to the Acceptance and Sensory Profiles of Concentrated Liquid Coffees: An Untargeted Metabolomics Approach
by: Mónica Quintero, et al.
Published: (2022-02-01)

An Experimental Design Approach to Quantitative Expression for Quality Control of a Multicomponent Antidiabetic Formulation by the HILIC Method
by: Mahesh Attimarad, et al.
Published: (2022-05-01)

Untargeted LC-QTOF (ESI +) MS Analysis of Small Serum Metabolites Related to Prostate Cancer and Prostate Specific Antigen
by: Ramona Maria Maxim, et al.
Published: (2014-11-01)

Untargeted metabolomics reveal sex-specific and non-specific redox-modulating metabolites in kidneys following binge drinking
by: Daniel Rafferty, et al.
Published: (2023-06-01)

Blood Metabolomic Profiling Confirms and Identifies Biomarkers of Food Intake
by: Julia Langenau, et al.
Published: (2020-11-01)

Elucidating Softening Mechanism of Honey Peach (<i>Prunus persica</i> L.) Stored at Ambient Temperature Using Untargeted Metabolomics Based on Liquid Chromatography-Mass Spectrometry
by: Xiaoxue Kong, et al.
Published: (2023-11-01)

MAW: the reproducible Metabolome Annotation Workflow for untargeted tandem mass spectrometry
by: Mahnoor Zulfiqar, et al.
Published: (2023-03-01)

Untargeted metabolomics reveal rhizosphere metabolites mechanisms on continuous ramie cropping
by: Yafen Fu, et al.
Published: (2023-08-01)

Simultaneous Quantitation and Discovery (SQUAD) Analysis: Combining the Best of Targeted and Untargeted Mass Spectrometry-Based Metabolomics
by: Bashar Amer, et al.
Published: (2023-05-01)

Comparison of Widely Targeted Metabolomics and Untargeted Metabolomics of Wild <i>Ophiocordyceps sinensis</i>
by: Jinna Zhou, et al.
Published: (2022-06-01)

METABOLÔMICA: DEFINIÇÕES, ESTADO-DA-ARTE E APLICAÇÕES REPRESENTATIVAS
by: Gisele A. B. Canuto, et al.

Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis
by: Henna Myllymäki, et al.
Published: (2021-08-01)

Metabolomic profiles as a new understanding of disease processes
by: O. Yu. Zolnikova, et al.
Published: (2022-05-01)