Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review
Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and M...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/2/140 |
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| author | Martin Scoglio Gabriel Bronz Pietro O. Rinoldi Pietro B. Faré Céline Betti Mario G. Bianchetti Giacomo D. Simonetti Viola Gennaro Samuele Renzi Sebastiano A. G. Lava Gregorio P. Milani |
| author_facet | Martin Scoglio Gabriel Bronz Pietro O. Rinoldi Pietro B. Faré Céline Betti Mario G. Bianchetti Giacomo D. Simonetti Viola Gennaro Samuele Renzi Sebastiano A. G. Lava Gregorio P. Milani |
| author_sort | Martin Scoglio |
| collection | DOAJ |
| description | Aminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Databases searched included United States National Library of Medicine, Excerpta Medica, and Web of Science. For the final analysis, we evaluated 46 reports, published after 1960, describing 82 cases. A total of 286 electrolyte and acid-base disorders were reported. Hypomagnesemia, hypokalemia, and hypocalcemia were reported in more than three quarter of cases. Further disorders were, in decreasing order of frequency, metabolic alkalosis, hyponatremia, hypophosphatemia, hypouricemia, hypernatremia, and metabolic acidosis. Six electrolyte and acid-base disorders were reported in seven cases, five in 12 cases, four in 16 cases, three in 31 cases, two in 11 cases, and one in five cases. Laboratory features consistent with a loop of Henle/distal tubular dysfunction were noted in 56 (68%), with a proximal tubular dysfunction in three (3.7%), and with a mixed dysfunction in five (6.1%) cases. The laboratory abnormality was unclassified in the remaining 18 (22%) cases. Treatment with aminoglycosides or colistin may trigger a proximal tubular or, more frequently, a loop of Henle/distal tubular dysfunction. |
| first_indexed | 2024-03-09T06:16:40Z |
| format | Article |
| id | doaj.art-7afc0815e39449f6b6e46ea11ac0f3f6 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T06:16:40Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-7afc0815e39449f6b6e46ea11ac0f3f62023-12-03T11:52:02ZengMDPI AGAntibiotics2079-63822021-02-0110214010.3390/antibiotics10020140Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic ReviewMartin Scoglio0Gabriel Bronz1Pietro O. Rinoldi2Pietro B. Faré3Céline Betti4Mario G. Bianchetti5Giacomo D. Simonetti6Viola Gennaro7Samuele Renzi8Sebastiano A. G. Lava9Gregorio P. Milani10Faculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandFaculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandFaculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandDepartment of Internal Medicine, Ospedale La Carità, Ente Ospedaliero Cantonale, 6600 Locarno, SwitzerlandFaculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandFaculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandFaculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandFaculty of Biomedicine, Università della Svizzera Italiana, 6900 Lugano, SwitzerlandDivision of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON M5G 1X8, CanadaPediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, 1011 Lausanne, SwitzerlandDepartment of Pediatrics, Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Ente Ospedaliero Cantonale, 6500 Bellinzona, SwitzerlandAminoglycoside or colistin therapy may alter the renal tubular function without decreasing the glomerular filtration rate. This association has never been extensively investigated. We conducted a systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses recommendations. Databases searched included United States National Library of Medicine, Excerpta Medica, and Web of Science. For the final analysis, we evaluated 46 reports, published after 1960, describing 82 cases. A total of 286 electrolyte and acid-base disorders were reported. Hypomagnesemia, hypokalemia, and hypocalcemia were reported in more than three quarter of cases. Further disorders were, in decreasing order of frequency, metabolic alkalosis, hyponatremia, hypophosphatemia, hypouricemia, hypernatremia, and metabolic acidosis. Six electrolyte and acid-base disorders were reported in seven cases, five in 12 cases, four in 16 cases, three in 31 cases, two in 11 cases, and one in five cases. Laboratory features consistent with a loop of Henle/distal tubular dysfunction were noted in 56 (68%), with a proximal tubular dysfunction in three (3.7%), and with a mixed dysfunction in five (6.1%) cases. The laboratory abnormality was unclassified in the remaining 18 (22%) cases. Treatment with aminoglycosides or colistin may trigger a proximal tubular or, more frequently, a loop of Henle/distal tubular dysfunction.https://www.mdpi.com/2079-6382/10/2/140dyselectrolytemiaaminoglycosidescolistinhypomagnesemiahypokalemiahypocalcemia |
| spellingShingle | Martin Scoglio Gabriel Bronz Pietro O. Rinoldi Pietro B. Faré Céline Betti Mario G. Bianchetti Giacomo D. Simonetti Viola Gennaro Samuele Renzi Sebastiano A. G. Lava Gregorio P. Milani Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review Antibiotics dyselectrolytemia aminoglycosides colistin hypomagnesemia hypokalemia hypocalcemia |
| title | Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review |
| title_full | Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review |
| title_fullStr | Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review |
| title_full_unstemmed | Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review |
| title_short | Electrolyte and Acid-Base Disorders Triggered by Aminoglycoside or Colistin Therapy: A Systematic Review |
| title_sort | electrolyte and acid base disorders triggered by aminoglycoside or colistin therapy a systematic review |
| topic | dyselectrolytemia aminoglycosides colistin hypomagnesemia hypokalemia hypocalcemia |
| url | https://www.mdpi.com/2079-6382/10/2/140 |
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