Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography
Cathrine M Keiner,1 Hao Zhou,2 Qinqin Zhang,2 Ruikang K Wang,2 Nicholas T Rinella,1 Catherine E Oldenburg,1,3 Jacque L Duncan,1 Daniel M Schwartz11Department of Ophthalmology, University of California, San Francisco, CA, USA; 2Department of Bioengineering, University of Washington, Seattle, WA, USA;...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-08-01
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| Series: | Clinical Ophthalmology |
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| Online Access: | https://www.dovepress.com/quantifying-choriocapillaris-hypoperfusion-in-patients-with-choroidal--peer-reviewed-article-OPTH |
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| author | Keiner CM Zhou H Zhang Q Wang RK Rinella NT Oldenburg CE Duncan JL Schwartz DM |
| author_facet | Keiner CM Zhou H Zhang Q Wang RK Rinella NT Oldenburg CE Duncan JL Schwartz DM |
| author_sort | Keiner CM |
| collection | DOAJ |
| description | Cathrine M Keiner,1 Hao Zhou,2 Qinqin Zhang,2 Ruikang K Wang,2 Nicholas T Rinella,1 Catherine E Oldenburg,1,3 Jacque L Duncan,1 Daniel M Schwartz11Department of Ophthalmology, University of California, San Francisco, CA, USA; 2Department of Bioengineering, University of Washington, Seattle, WA, USA; 3Francis I. Proctor Foundation, University of California, San Francisco, CA, USACorrespondence: Daniel M SchwartzDepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94117, USATel +1 415 476 1152Email dan.schwartz@ucsf.eduPurpose: To compare choriocapillaris flow voids (FV) in patients with neovascular age-related macular degeneration (AMD) with age-matched normal controls using swept-source optical coherence tomography angiography (SS-OCTA).Patients and methods: Eleven eyes of 11 subjects with neovascular AMD and 11 eyes of 11 age-similar normal subjects were imaged using SS-OCTA with a 6x6mm scanning pattern. Choriocapillaris FV, defined as a percentage of regions determined to have flow deficits divided by the total scanned region, was measured using a one standard deviation thresholding algorithm developed from a database of age-similar normal subjects.Results: Choriocapillaris FV was more extensive in patients with choroidal neovascularization (CNV) compared to age-similar normal subjects (FV: 20.56±4.95, 95% CI: 17.64–23.49 vs FV: 10.95±2.08, 95% CI: 9.73–12.18, respectively; P=0.0001). FV within a two-degree margin surrounding CNV in wet AMD subjects (FV: 35.04±9.34; 95% CI: 29.52–40.56) was increased compared to normal subjects (P<0.001). FV of the region outside the two-degree margin surrounding CNV (FV: 19.61±6.08, 95% CI: 16.02–23.20) was increased compared to age-similar controls (P=0.0002). In neovascular AMD eyes, FV was greater within two degrees of the margin of CNV than in the remainder of the macula (margin: 35.04±9.34; outside: 19.61±6.08; P=0.002), and CNV lesion area was positively correlated with FV (correlation coefficient =0.84; 95% CI: 0.49–0.96; P=0.001).Conclusion: Choriocapillaris flow deficits were significantly greater in wet AMD subjects than age-similar normal subjects, suggesting that choroidal hypo-perfusion likely plays a role in the pathogenesis of neovascular AMD. Recognition of choriocapillaris flow deficits in patients with AMD may facilitate earlier diagnosis and identify alternative therapeutic targets for this multifactorial disease.Keywords: flow void, AMD, OCT angiography, OCTA |
| first_indexed | 2024-12-17T10:54:40Z |
| format | Article |
| id | doaj.art-7afc492592bc4a12b747ae8a8e033fff |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-17T10:54:40Z |
| publishDate | 2019-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-7afc492592bc4a12b747ae8a8e033fff2022-12-21T21:51:53ZengDove Medical PressClinical Ophthalmology1177-54832019-08-01Volume 131613162048118Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiographyKeiner CMZhou HZhang QWang RKRinella NTOldenburg CEDuncan JLSchwartz DMCathrine M Keiner,1 Hao Zhou,2 Qinqin Zhang,2 Ruikang K Wang,2 Nicholas T Rinella,1 Catherine E Oldenburg,1,3 Jacque L Duncan,1 Daniel M Schwartz11Department of Ophthalmology, University of California, San Francisco, CA, USA; 2Department of Bioengineering, University of Washington, Seattle, WA, USA; 3Francis I. Proctor Foundation, University of California, San Francisco, CA, USACorrespondence: Daniel M SchwartzDepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94117, USATel +1 415 476 1152Email dan.schwartz@ucsf.eduPurpose: To compare choriocapillaris flow voids (FV) in patients with neovascular age-related macular degeneration (AMD) with age-matched normal controls using swept-source optical coherence tomography angiography (SS-OCTA).Patients and methods: Eleven eyes of 11 subjects with neovascular AMD and 11 eyes of 11 age-similar normal subjects were imaged using SS-OCTA with a 6x6mm scanning pattern. Choriocapillaris FV, defined as a percentage of regions determined to have flow deficits divided by the total scanned region, was measured using a one standard deviation thresholding algorithm developed from a database of age-similar normal subjects.Results: Choriocapillaris FV was more extensive in patients with choroidal neovascularization (CNV) compared to age-similar normal subjects (FV: 20.56±4.95, 95% CI: 17.64–23.49 vs FV: 10.95±2.08, 95% CI: 9.73–12.18, respectively; P=0.0001). FV within a two-degree margin surrounding CNV in wet AMD subjects (FV: 35.04±9.34; 95% CI: 29.52–40.56) was increased compared to normal subjects (P<0.001). FV of the region outside the two-degree margin surrounding CNV (FV: 19.61±6.08, 95% CI: 16.02–23.20) was increased compared to age-similar controls (P=0.0002). In neovascular AMD eyes, FV was greater within two degrees of the margin of CNV than in the remainder of the macula (margin: 35.04±9.34; outside: 19.61±6.08; P=0.002), and CNV lesion area was positively correlated with FV (correlation coefficient =0.84; 95% CI: 0.49–0.96; P=0.001).Conclusion: Choriocapillaris flow deficits were significantly greater in wet AMD subjects than age-similar normal subjects, suggesting that choroidal hypo-perfusion likely plays a role in the pathogenesis of neovascular AMD. Recognition of choriocapillaris flow deficits in patients with AMD may facilitate earlier diagnosis and identify alternative therapeutic targets for this multifactorial disease.Keywords: flow void, AMD, OCT angiography, OCTAhttps://www.dovepress.com/quantifying-choriocapillaris-hypoperfusion-in-patients-with-choroidal--peer-reviewed-article-OPTHFlow voidAMDOCT angiographyOCTA |
| spellingShingle | Keiner CM Zhou H Zhang Q Wang RK Rinella NT Oldenburg CE Duncan JL Schwartz DM Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography Clinical Ophthalmology Flow void AMD OCT angiography OCTA |
| title | Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography |
| title_full | Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography |
| title_fullStr | Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography |
| title_full_unstemmed | Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography |
| title_short | Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography |
| title_sort | quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept source oct angiography |
| topic | Flow void AMD OCT angiography OCTA |
| url | https://www.dovepress.com/quantifying-choriocapillaris-hypoperfusion-in-patients-with-choroidal--peer-reviewed-article-OPTH |
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