Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
The aim of this work was to find out the optimal concentration of gelling agents or their optimal combination in the olive oil environment to stabilise the suspension of chondroitin sulphate. Purified olive oil was structured with rice bran wax or a combination of gelators – soy lecithin and sorbita...
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| Format: | Article |
| Language: | English |
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Sciendo
2021-09-01
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| Series: | European Pharmaceutical Journal |
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| Online Access: | https://doi.org/10.2478/afpuc-2021-0006 |
| _version_ | 1819000890965622784 |
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| author | Zima J. |
| author_facet | Zima J. |
| author_sort | Zima J. |
| collection | DOAJ |
| description | The aim of this work was to find out the optimal concentration of gelling agents or their optimal combination in the olive oil environment to stabilise the suspension of chondroitin sulphate. Purified olive oil was structured with rice bran wax or a combination of gelators – soy lecithin and sorbitan tristearate. Rice bran wax creates a viscous fluid without a gel structure. The combination of soy lecithin and sorbitan tristearate forms a gel structure from 5 wt.% of the concentration. The optimal ratio of soy lecithin and sorbitan tristearate was found to be 3:2 wt.%. Oleogel was immobile at temperatures below 8°C; on increasing the temperature, it changed to a viscous liquid. The oleogel environment opens new possibilities for creating oral route immunotherapy approaches such as glycoprotein-derived macrophage activating factor-derived immunotherapy. |
| first_indexed | 2024-12-20T22:40:31Z |
| format | Article |
| id | doaj.art-7afce6ca3ec047c98cd655c85364079b |
| institution | Directory Open Access Journal |
| issn | 2453-6725 |
| language | English |
| last_indexed | 2024-12-20T22:40:31Z |
| publishDate | 2021-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | European Pharmaceutical Journal |
| spelling | doaj.art-7afce6ca3ec047c98cd655c85364079b2022-12-21T19:24:29ZengSciendoEuropean Pharmaceutical Journal2453-67252021-09-01681929310.2478/afpuc-2021-0006Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF ImmunotherapyZima J.0Comenius University, Faculty of Pharmacy, Department of Galenic Pharmacy, Odbojárov 10, SK-832 32BratislavaThe aim of this work was to find out the optimal concentration of gelling agents or their optimal combination in the olive oil environment to stabilise the suspension of chondroitin sulphate. Purified olive oil was structured with rice bran wax or a combination of gelators – soy lecithin and sorbitan tristearate. Rice bran wax creates a viscous fluid without a gel structure. The combination of soy lecithin and sorbitan tristearate forms a gel structure from 5 wt.% of the concentration. The optimal ratio of soy lecithin and sorbitan tristearate was found to be 3:2 wt.%. Oleogel was immobile at temperatures below 8°C; on increasing the temperature, it changed to a viscous liquid. The oleogel environment opens new possibilities for creating oral route immunotherapy approaches such as glycoprotein-derived macrophage activating factor-derived immunotherapy.https://doi.org/10.2478/afpuc-2021-0006oleogeledible oleogelatorslecithinchondroitin sulphate suspension |
| spellingShingle | Zima J. Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy European Pharmaceutical Journal oleogel edible oleogelators lecithin chondroitin sulphate suspension |
| title | Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy |
| title_full | Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy |
| title_fullStr | Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy |
| title_full_unstemmed | Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy |
| title_short | Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy |
| title_sort | suspension of glycosaminoglycans in oleogel environment and application perspective in gcmaf immunotherapy |
| topic | oleogel edible oleogelators lecithin chondroitin sulphate suspension |
| url | https://doi.org/10.2478/afpuc-2021-0006 |
| work_keys_str_mv | AT zimaj suspensionofglycosaminoglycansinoleogelenvironmentandapplicationperspectiveingcmafimmunotherapy |