Phillygenin Attenuates Carbon Tetrachloride-Induced Liver Fibrosis via Modulating Inflammation and Gut Microbiota

Phillygenin Attenuates Carbon Tetrachloride-Induced Liver Fibrosis via Modulating Inflammation and Gut Microbiota

Liver fibrosis is a chronic pathological process that various pathogenic factors lead to abnormal hyperplasia of hepatic connective tissue, and its main feature is the excessive deposition of extracellular matrix. However, there are currently no drugs approved for the treatment of liver fibrosis. Ph...

Full description

Bibliographic Details
Main Authors:	Cheng Wang, Cheng Ma, Ke Fu, Li-Hong Gong, Ya-Fang Zhang, Hong-Lin Zhou, Yun-Xia Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Pharmacology
Subjects:	Phillygenin liver fibrosis gut microbiota intestinal barrier carbon tetrachloride
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.756924/full

Similar Items

Preparation of Phillygenin-Hyaluronic acid composite milk-derived exosomes and its anti-hepatic fibrosis effect
by: Lihong Gong, et al.
Published: (2023-12-01)

A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives
by: Cheng Wang, et al.
Published: (2023-10-01)

Synergistic anti-infectious bronchitis virus activity of Phillygenin combined Baicalin by modulating respiratory microbiota and improving metabolic disorders
by: Haipeng Feng, et al.
Published: (2024-02-01)

Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p
by: Cheng Ma, et al.
Published: (2023-03-01)

Phillygenin Inhibits Helicobacter pylori by Preventing Biofilm Formation and Inducing ATP Leakage
by: Ru-Jia Li, et al.
Published: (2022-04-01)

Dietary phillygenin supplementation ameliorates aflatoxin B1-induced oxidative stress, inflammation, and apoptosis in chicken liver
by: Jing Guo, et al.
Published: (2022-05-01)

Therapeutic effect of demethylated hydroxylated phillygenin derivative on Helicobacter pylori infection
by: Ru-Jia Li, et al.
Published: (2023-05-01)

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice
by: Peng Zhang, et al.
Published: (2023-07-01)

Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways
by: Huan-Huan Xue, et al.
Published: (2023-01-01)

Hawthorn Herbal Preparation from <i>Crataegus oxyacantha</i> Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation
by: Alaaeldin Ahmed Hamza, et al.
Published: (2020-11-01)

Self-Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation
by: Lingzhi Wang, et al.
Published: (2020-02-01)

Iron deposition causes oxidative stress, inflammation and fibrosis in carbon tetrachloride-induced liver dysfunction in rats
by: Hasan Mahmud Reza, et al.
Published: (2015-02-01)

Potential protective role of spirulina algae and/or aminoguanidine on carbon tetrachloride induced liver fibrosis in rats.
by: Shawky, M.F., et al.
Published: (2023-12-01)

Anti-fibrotic effect of bovine colostrum in carbon tetrachloride-induced hepatic fibrosis
by: Dong Hyun Sinn, et al.
Published: (2017-06-01)

Hepatoprotective effect of dipeptidyl peptidase-4 inhibitor sitagliptin against carbon tetrachloride-induced liver fibrosis in mice
by: Ahmed A.N Ahmed, et al.
Published: (2021-01-01)

Hepatoprotective effect of Matrine salvianolic acid B salt on Carbon Tetrachloride-Induced Hepatic Fibrosis
by: Gao Hong-Ying, et al.
Published: (2012-05-01)

Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice
by: Han Zheng, et al.
Published: (2018-12-01)

Carbon tetrachloride
by: 8096 British Standards Institution

The Differential and Dynamic Progression of Hepatic Inflammation and Immune Responses During Liver Fibrosis Induced by Schistosoma japonicum or Carbon Tetrachloride in Mice
by: Li-Jun Song, et al.
Published: (2020-10-01)

Evaluation of the Effect of Hydroalcoholic Extract of Dracocephalum Kotschyi Boiss on Hepatic Fibrosis Induced by Carbon Tetrachloride in Rats
by: Mohammad Atabak, et al.
Published: (2022-06-01)

Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca<sub>v</sub>2.2 Calcium Channels
by: Ming-Yi Lee, et al.
Published: (2024-02-01)

Gut microbes combined with metabolomics reveal the protective effects of Qijia Rougan decoction against CCl4-induced hepatic fibrosis
by: Xue Li, et al.
Published: (2024-03-01)

Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs
by: Shukai Zhan, et al.
Published: (2021-07-01)

Effect of crude Ganoderma applanatum polysaccharides as a renoprotective agent against carbon tetrachloride-induced early kidney fibrosis in mice
by: Raden Joko Kuncoroningrat Susilo, et al.
Published: (2022-04-01)

Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis
by: Liru Xue, et al.
Published: (2022-09-01)

The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis
by: Z.R. Wang, et al.
Published: (2011-02-01)

The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis
by: Z.R. Wang, et al.
Published: (2011-02-01)

Consumption of Goats’ Milk Protects Mice From Carbon Tetrachloride-Induced Acute Hepatic Injury and Improves the Associated Gut Microbiota Imbalance
by: Jiachao Zhang, et al.
Published: (2018-05-01)

Intestinal Inflammation and Alterations in the Gut Microbiota in Cystic Fibrosis: A Review of the Current Evidence, Pathophysiology and Future Directions
by: Rachel Y. Tam, et al.
Published: (2022-01-01)

Direct-acting antivirals sofosbuvir and daclatasvir attenuate carbon tetrachloride-induced liver fibrosis in mice
by: Mayadah M. Abdelsalam, et al.
Published: (2023-03-01)

Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats
by: Masatsugu Ohara, et al.
Published: (2018-07-01)

Gut Microbiome and Organ Fibrosis
by: Carolina F. F. A. Costa, et al.
Published: (2022-01-01)

Inhibitory effects of Curcumae Radix carbonisata-based carbon dots against liver fibrosis induced by carbon tetrachloride in mice
by: Yusheng Zhao, et al.
Published: (2024-12-01)

Attenuation of oxidative damage-associated hepatotoxicity by piperine in CCl4-induced liver fibrosis
by: Adil Farooq Wali, et al.
Published: (2021-12-01)

Current understanding of the gut microbiota shaping mechanisms
by: Cherng-Shyang Chang, et al.
Published: (2019-08-01)

Kangxianling formula attenuates renal fibrosis by regulating gut microbiota
by: Pengyu Tao, et al.
Published: (2024-03-01)

Aerosol products, sterilants, miscellaneous uses and carbon tetrachloride
Published: (1991)

The antidiabetic effect and potential mechanisms of natural polysaccharides based on the regulation of gut microbiota
by: Wangting Zhou, et al.
Published: (2020-12-01)

NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis
by: Akouavi Julite I. Quenum, et al.
Published: (2021-10-01)

Sasa veitchii extract protects against carbon tetrachloride-induced hepatic fibrosis in mice
by: Hiroki Yoshioka, et al.
Published: (2018-10-01)