Pharmacokinetics and Pharmacodynamics of (S)-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats

Pharmacokinetics and Pharmacodynamics of (S)-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats

The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in a gout-type pain model. 3.2 mg/kg of (S)-ketoprofen alone and combined with 17.8 mg/kg of caffeine were administered to Wistar rats...

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Bibliographic Details
Main Authors: Raúl Medina-López, Nancy Vara-Gama, Olivia Soria-Arteche, Luis A. Moreno-Rocha, Francisco J. López-Muñoz
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Pharmaceutics
Subjects:
(S)-ketoprofen
caffeine
pharmacokinetics
pharmacodynamics
PIFIR model
Online Access:http://www.mdpi.com/1999-4923/10/1/20

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