Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft
Background For patients with neuropathy, vasculopathy, and impairment of wound healing, treatment of a diabetic foot ulcer poses many challenges. A large number of dermal analogues have been invented in an effort to overcome these challenges. Matriderm, a dermal analogue, is made from bovine collag...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2013-07-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2013.40.4.403 |
| _version_ | 1798041730654666752 |
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| author | Hyojin Jeon Junhyung Kim Hyeonjung Yeo Hoijoon Jeong Daegu Son Kihwan Han |
| author_facet | Hyojin Jeon Junhyung Kim Hyeonjung Yeo Hoijoon Jeong Daegu Son Kihwan Han |
| author_sort | Hyojin Jeon |
| collection | DOAJ |
| description | Background For patients with neuropathy, vasculopathy, and impairment of wound healing, treatment of a diabetic foot ulcer poses many challenges. A large number of dermal analogues have been invented in an effort to overcome these challenges. Matriderm, a dermal analogue, is made from bovine collagen and elastin. This study was conducted in order to evaluate the effectiveness of Matriderm for treatment of diabetic foot ulcers, in comparison with skin grafting.
Methods Sixty patients with diabetic foot ulcer were included in this prospective study. The average age of the patients, who had type II diabetes mellitus, was 58 years old. The patients were allocated to an experimental or control group with their consents. The patients were selected with their consent for inclusion in an experimental group and a control group. Patients in the experimental group received a Matriderm appliance and a split-thickness skin graft, while those in the control group received only a split-thickness skin graft.
Results A shorter hospitalization period (7.52 weeks) was observed in the experimental group than in the control group (9.22 weeks), and a shorter period of time (8.61 weeks) was required for complete healing, compared with the control group (12.94 weeks), with statistical significance (P<0.05). A higher elasticity ratio of the affected side to the non-affected side was observed in the experimental group, compared with the control group (P<0.01).
Conclusions Matriderm enables effective healing and improves elasticity in treatment of patients with diabetic foot ulcer. |
| first_indexed | 2024-04-11T22:25:36Z |
| format | Article |
| id | doaj.art-7aff1acca9844e1b9ebd1b03ab5efe9d |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-11T22:25:36Z |
| publishDate | 2013-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-7aff1acca9844e1b9ebd1b03ab5efe9d2022-12-22T03:59:45ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712013-07-01400440340810.5999/aps.2013.40.4.403Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin GraftHyojin Jeon0Junhyung Kim1Hyeonjung Yeo2Hoijoon Jeong3Daegu Son4Kihwan Han5Department of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, KoreaDepartment of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, KoreaDepartment of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, KoreaDepartment of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, KoreaDepartment of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, KoreaDepartment of Plastic and Reconstructive Surgery, Keimyung University School of Medicine, Daegu, KoreaBackground For patients with neuropathy, vasculopathy, and impairment of wound healing, treatment of a diabetic foot ulcer poses many challenges. A large number of dermal analogues have been invented in an effort to overcome these challenges. Matriderm, a dermal analogue, is made from bovine collagen and elastin. This study was conducted in order to evaluate the effectiveness of Matriderm for treatment of diabetic foot ulcers, in comparison with skin grafting. Methods Sixty patients with diabetic foot ulcer were included in this prospective study. The average age of the patients, who had type II diabetes mellitus, was 58 years old. The patients were allocated to an experimental or control group with their consents. The patients were selected with their consent for inclusion in an experimental group and a control group. Patients in the experimental group received a Matriderm appliance and a split-thickness skin graft, while those in the control group received only a split-thickness skin graft. Results A shorter hospitalization period (7.52 weeks) was observed in the experimental group than in the control group (9.22 weeks), and a shorter period of time (8.61 weeks) was required for complete healing, compared with the control group (12.94 weeks), with statistical significance (P<0.05). A higher elasticity ratio of the affected side to the non-affected side was observed in the experimental group, compared with the control group (P<0.01). Conclusions Matriderm enables effective healing and improves elasticity in treatment of patients with diabetic foot ulcer.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2013.40.4.403skindiabetes complicationsskin transplantation |
| spellingShingle | Hyojin Jeon Junhyung Kim Hyeonjung Yeo Hoijoon Jeong Daegu Son Kihwan Han Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft Archives of Plastic Surgery skin diabetes complications skin transplantation |
| title | Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft |
| title_full | Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft |
| title_fullStr | Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft |
| title_full_unstemmed | Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft |
| title_short | Treatment of Diabetic Foot Ulcer Using Matriderm In Comparison with a Skin Graft |
| title_sort | treatment of diabetic foot ulcer using matriderm in comparison with a skin graft |
| topic | skin diabetes complications skin transplantation |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2013.40.4.403 |
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