Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre
Abstract Background Fungal peritonitis (FP) is an infrequent but serious complication in children undergoing peritoneal dialysis (PD). This study aimed to explore the risk factors, clinical manifestations, causative organisms, fungal susceptibility findings, and outcomes of FP in children from Saudi...
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| Format: | Article |
| Language: | English |
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BMC
2020-09-01
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| Series: | BMC Nephrology |
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| Online Access: | http://link.springer.com/article/10.1186/s12882-020-02014-1 |
| _version_ | 1828415455028576256 |
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| author | Mohammed Alsuhaibani Egab Aldosari Khawla A. Rahim Saeed Alzabli Dayel Alshahrani |
| author_facet | Mohammed Alsuhaibani Egab Aldosari Khawla A. Rahim Saeed Alzabli Dayel Alshahrani |
| author_sort | Mohammed Alsuhaibani |
| collection | DOAJ |
| description | Abstract Background Fungal peritonitis (FP) is an infrequent but serious complication in children undergoing peritoneal dialysis (PD). This study aimed to explore the risk factors, clinical manifestations, causative organisms, fungal susceptibility findings, and outcomes of FP in children from Saudi Arabia. Methods In this case–control study, the medical records and laboratory results of paediatric patients aged 0–14 years who underwent PD were reviewed for FP episodes. All FP episodes were matched with PD-related bacterial peritonitis episodes (1:4 ratio). Results A total of 194 episodes of PD-related peritonitis occurred between 2007 and 2017, among which 11 were FP episodes (5.6%), representing a rate of 0.03 episodes per patient-year. Of these 11 episodes, 9 were caused by Candida species (82%). Compared with the bacterial peritonitis group, the FP group had a higher proportion of patients with congenital/infantile nephrotic syndrome (p = 0.005) and those younger than 5 years of age (p = 0.001). We observed a higher rate of catheter removal in the FP group than in the bacterial peritonitis group (p < 0.001); however, 1 patient died despite catheter removal. Moreover, 75% of Candida species isolates were susceptible to fluconazole. Conclusions This study revealed that FP is associated with a significant risk of peritoneal membrane failure among children undergoing PD. Therefore, early diagnosis and prompt management are essential. We also found that congenital/infantile nephrotic syndrome and young age (5 years old or younger) were risk factors for FP in children undergoing PD. |
| first_indexed | 2024-12-10T13:45:07Z |
| format | Article |
| id | doaj.art-7b019b90ec334dc7b77136cce9098bc9 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-10T13:45:07Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-7b019b90ec334dc7b77136cce9098bc92022-12-22T01:46:28ZengBMCBMC Nephrology1471-23692020-09-012111610.1186/s12882-020-02014-1Fungal peritonitis in children on peritoneal dialysis at a tertiary care CentreMohammed Alsuhaibani0Egab Aldosari1Khawla A. Rahim2Saeed Alzabli3Dayel Alshahrani4Department of Paediatrics, College of Medicine, Qassim UniversityGeneral Paediatric Department, King Fahad Medical CityDepartment of Paediatric Nephrology, King Fahad Medical CityDepartment of Paediatric Nephrology, King Fahad Medical CityDepartment of Paediatric Infectious Diseases, King Fahad Medical CityAbstract Background Fungal peritonitis (FP) is an infrequent but serious complication in children undergoing peritoneal dialysis (PD). This study aimed to explore the risk factors, clinical manifestations, causative organisms, fungal susceptibility findings, and outcomes of FP in children from Saudi Arabia. Methods In this case–control study, the medical records and laboratory results of paediatric patients aged 0–14 years who underwent PD were reviewed for FP episodes. All FP episodes were matched with PD-related bacterial peritonitis episodes (1:4 ratio). Results A total of 194 episodes of PD-related peritonitis occurred between 2007 and 2017, among which 11 were FP episodes (5.6%), representing a rate of 0.03 episodes per patient-year. Of these 11 episodes, 9 were caused by Candida species (82%). Compared with the bacterial peritonitis group, the FP group had a higher proportion of patients with congenital/infantile nephrotic syndrome (p = 0.005) and those younger than 5 years of age (p = 0.001). We observed a higher rate of catheter removal in the FP group than in the bacterial peritonitis group (p < 0.001); however, 1 patient died despite catheter removal. Moreover, 75% of Candida species isolates were susceptible to fluconazole. Conclusions This study revealed that FP is associated with a significant risk of peritoneal membrane failure among children undergoing PD. Therefore, early diagnosis and prompt management are essential. We also found that congenital/infantile nephrotic syndrome and young age (5 years old or younger) were risk factors for FP in children undergoing PD.http://link.springer.com/article/10.1186/s12882-020-02014-1PeritonealNephroticCandidaCatheterDialysisFungal |
| spellingShingle | Mohammed Alsuhaibani Egab Aldosari Khawla A. Rahim Saeed Alzabli Dayel Alshahrani Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre BMC Nephrology Peritoneal Nephrotic Candida Catheter Dialysis Fungal |
| title | Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre |
| title_full | Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre |
| title_fullStr | Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre |
| title_full_unstemmed | Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre |
| title_short | Fungal peritonitis in children on peritoneal dialysis at a tertiary care Centre |
| title_sort | fungal peritonitis in children on peritoneal dialysis at a tertiary care centre |
| topic | Peritoneal Nephrotic Candida Catheter Dialysis Fungal |
| url | http://link.springer.com/article/10.1186/s12882-020-02014-1 |
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