Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents
Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract of unknown etiology. The diagnosis of IBS is made clinically, using symptom-based criteria such as the Manning or Rome criteria. Medical therapy for this condition has traditionally been directed towards sy...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-03-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756283X10387203 |
| _version_ | 1828837480195948544 |
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| author | Anita Sainsbury Alexander C. Ford |
| author_facet | Anita Sainsbury Alexander C. Ford |
| author_sort | Anita Sainsbury |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract of unknown etiology. The diagnosis of IBS is made clinically, using symptom-based criteria such as the Manning or Rome criteria. Medical therapy for this condition has traditionally been directed towards symptom relief, using fiber or antispasmodic agents. In recent years, emerging data have confirmed the efficacy of antidepressants, psychological therapies, 5-HT 3 antagonists, 5-HT 4 agonists, and probiotics in the short-term treatment of IBS, although whether these therapies influence the long-term course of the disease is unknown. Increasing knowledge regarding the pathophysiological mechanisms underlying IBS has resulted in a number of novel molecular treatments, which show promise. These include therapies targeting gastrointestinal mucosal chloride channels and guanylate cyclase-C receptors, as well as highly selective agents influencing serotonergic transmission that, at the time of writing, do not appear to have any severe deleterious effects. In this article we provide a summary of current and emerging therapies in this field. |
| first_indexed | 2024-12-12T18:41:45Z |
| format | Article |
| id | doaj.art-7b048c6f9fa6462f822f60d512bc747e |
| institution | Directory Open Access Journal |
| issn | 1756-283X 1756-2848 |
| language | English |
| last_indexed | 2024-12-12T18:41:45Z |
| publishDate | 2011-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-7b048c6f9fa6462f822f60d512bc747e2022-12-22T00:15:37ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-283X1756-28482011-03-01410.1177/1756283X10387203Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agentsAnita SainsburyAlexander C. FordIrritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract of unknown etiology. The diagnosis of IBS is made clinically, using symptom-based criteria such as the Manning or Rome criteria. Medical therapy for this condition has traditionally been directed towards symptom relief, using fiber or antispasmodic agents. In recent years, emerging data have confirmed the efficacy of antidepressants, psychological therapies, 5-HT 3 antagonists, 5-HT 4 agonists, and probiotics in the short-term treatment of IBS, although whether these therapies influence the long-term course of the disease is unknown. Increasing knowledge regarding the pathophysiological mechanisms underlying IBS has resulted in a number of novel molecular treatments, which show promise. These include therapies targeting gastrointestinal mucosal chloride channels and guanylate cyclase-C receptors, as well as highly selective agents influencing serotonergic transmission that, at the time of writing, do not appear to have any severe deleterious effects. In this article we provide a summary of current and emerging therapies in this field.https://doi.org/10.1177/1756283X10387203 |
| spellingShingle | Anita Sainsbury Alexander C. Ford Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents Therapeutic Advances in Gastroenterology |
| title | Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents |
| title_full | Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents |
| title_fullStr | Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents |
| title_full_unstemmed | Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents |
| title_short | Treatment of irritable bowel syndrome: beyond fiber and antispasmodic agents |
| title_sort | treatment of irritable bowel syndrome beyond fiber and antispasmodic agents |
| url | https://doi.org/10.1177/1756283X10387203 |
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