Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.

The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We tested neuroprotective effects of the synthetic triterpenoid CDDO-MA, a potent activator of the Nrf2/ARE signaling. CDDO-MA...

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Bibliographic Details
Main Authors: Lichuan Yang, Noel Y Calingasan, Bobby Thomas, Rajnish K Chaturvedi, Mahmoud Kiaei, Elizabeth J Wille, Karen T Liby, Charlotte Williams, Darlene Royce, Renee Risingsong, Eric S Musiek, Jason D Morrow, Michael Sporn, M Flint Beal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2684590?pdf=render

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