Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection
Background/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection. Materials and Methods: A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PC...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=3;spage=165;epage=170;aulast=Sun |
| _version_ | 1818331771559739392 |
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| author | Zhi-Gang Sun Li Yu Wei Gao Zhou Wang Liang-Ming Zhu |
| author_facet | Zhi-Gang Sun Li Yu Wei Gao Zhou Wang Liang-Ming Zhu |
| author_sort | Zhi-Gang Sun |
| collection | DOAJ |
| description | Background/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection.
Materials and Methods: A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect MUC1 at the mRNA level and were evaluated by immunohistochemistry (IHC) to detect MUC1 at the protein level.
Results: MUC1 mRNA was found in 74 cases by RT-PCR and MUC1 protein expression was found by IHC in 70 cases. Both MUC1 mRNA and protein expression correlated with pT (<0.05), pN (P < 0.01), and pTNM (<0.01). The 5-year survival rates of the patients were 39.8%. In univariate analysis, the 5-year survival rate in the ESCC patients was significantly associated with pT (P < 0.01), pN (P < 0.01), pTNM stage (P < 0.01), and MUC1 mRNA and protein expression (P < 0.05). In multivariate analysis, pN and MUC1 expression were the independent relevant factors.
Conclusion: MUC1 expression can become a useful marker to predict poor prognostic factors for 5-year survival rate in patients with ESCC after radical resection. |
| first_indexed | 2024-12-13T13:25:09Z |
| format | Article |
| id | doaj.art-7b07367266fc47c0bb76fbb166cabe2a |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-13T13:25:09Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-7b07367266fc47c0bb76fbb166cabe2a2022-12-21T23:44:18ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492018-01-0124316517010.4103/sjg.SJG_420_17Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resectionZhi-Gang SunLi YuWei GaoZhou WangLiang-Ming ZhuBackground/Aim: To investigate the clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma (ESCC) after radical resection. Materials and Methods: A total of 108 ESCC specimens were evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR) to detect MUC1 at the mRNA level and were evaluated by immunohistochemistry (IHC) to detect MUC1 at the protein level. Results: MUC1 mRNA was found in 74 cases by RT-PCR and MUC1 protein expression was found by IHC in 70 cases. Both MUC1 mRNA and protein expression correlated with pT (<0.05), pN (P < 0.01), and pTNM (<0.01). The 5-year survival rates of the patients were 39.8%. In univariate analysis, the 5-year survival rate in the ESCC patients was significantly associated with pT (P < 0.01), pN (P < 0.01), pTNM stage (P < 0.01), and MUC1 mRNA and protein expression (P < 0.05). In multivariate analysis, pN and MUC1 expression were the independent relevant factors. Conclusion: MUC1 expression can become a useful marker to predict poor prognostic factors for 5-year survival rate in patients with ESCC after radical resection.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=3;spage=165;epage=170;aulast=SunEsophageal cancerimmunohistochemistryMUC1prognosisreverse transcriptase-polymerase chain reaction |
| spellingShingle | Zhi-Gang Sun Li Yu Wei Gao Zhou Wang Liang-Ming Zhu Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection The Saudi Journal of Gastroenterology Esophageal cancer immunohistochemistry MUC1 prognosis reverse transcriptase-polymerase chain reaction |
| title | Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection |
| title_full | Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection |
| title_fullStr | Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection |
| title_full_unstemmed | Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection |
| title_short | Clinical and prognostic significance of MUC1 expression in patients with esophageal squamous cell carcinoma after radical resection |
| title_sort | clinical and prognostic significance of muc1 expression in patients with esophageal squamous cell carcinoma after radical resection |
| topic | Esophageal cancer immunohistochemistry MUC1 prognosis reverse transcriptase-polymerase chain reaction |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=3;spage=165;epage=170;aulast=Sun |
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