The association of insular stroke with lesion volume
The insula has been implicated in many sequelae of stroke. It is the area most commonly infarcted in people with post-stroke arrhythmias, loss of thermal sensation, hospital acquired pneumonia, and apraxia of speech. We hypothesized that some of these results reflect the fact that: (1) ischemic stro...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158216300067 |
| _version_ | 1819211019708268544 |
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| author | Nishanth Kodumuri Rajani Sebastian Cameron Davis Joseph Posner Eun Hye Kim Donna C. Tippett Amy Wright Argye E. Hillis |
| author_facet | Nishanth Kodumuri Rajani Sebastian Cameron Davis Joseph Posner Eun Hye Kim Donna C. Tippett Amy Wright Argye E. Hillis |
| author_sort | Nishanth Kodumuri |
| collection | DOAJ |
| description | The insula has been implicated in many sequelae of stroke. It is the area most commonly infarcted in people with post-stroke arrhythmias, loss of thermal sensation, hospital acquired pneumonia, and apraxia of speech. We hypothesized that some of these results reflect the fact that: (1) ischemic strokes that involve the insula are larger than strokes that exclude the insula (and therefore are associated with more common and persistent deficits); and (2) insular involvement is a marker of middle cerebral artery (MCA) occlusion. We analyzed MRI scans of 861 patients with acute ischemic hemispheric strokes unselected for functional deficits, and compared infarcts involving the insula to infarcts not involving the insula using t-tests for continuous variables and chi square tests for dichotomous variables. Mean infarct volume was larger for infarcts including the insula (n = 232) versus excluding the insula (n = 629): 65.8 ± 78.8 versus 10.2 ± 15.9 cm3 (p < 0.00001). Even when we removed lacunar infarcts, mean volume of non-lacunar infarcts that included insula (n = 775) were larger than non-lacunar infarcts (n = 227) that excluded insula: 67.0 cm3 ± 79.2 versus 11.5 cm3 ± 16.7 (p < 0.00001). Of infarcts in the 90th percentile for volume, 87% included the insula (χ2 = 181.8; p < 0.00001). Furthermore, 79.0% infarcts due to MCA occlusion included the insula; 78.5% of infarcts without MCA occlusion excluded the insula (χ2 = 93.1; p < 0.0001). The association between insular damage and acute or chronic sequelae likely often reflects the fact that insular infarct is a marker of large infarcts caused by occlusion of the MCA more than a specific role of the insula in a range of functions. Particularly in acute stroke, some deficits may also be due to ischemia of the MCA or ICA territory caused by large vessel occlusion. |
| first_indexed | 2024-12-23T06:20:25Z |
| format | Article |
| id | doaj.art-7b07ae9841bc4cad9a53ed8631661845 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-23T06:20:25Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
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| series | NeuroImage: Clinical |
| spelling | doaj.art-7b07ae9841bc4cad9a53ed86316618452022-12-21T17:57:12ZengElsevierNeuroImage: Clinical2213-15822016-01-0111C414510.1016/j.nicl.2016.01.007The association of insular stroke with lesion volumeNishanth Kodumuri0Rajani Sebastian1Cameron Davis2Joseph Posner3Eun Hye Kim4Donna C. Tippett5Amy Wright6Argye E. Hillis7NTR University of Health Sciences, Osmania Medical College, Hyderabad, Telangana 500095, IndiaDepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USADepartment of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USAThe insula has been implicated in many sequelae of stroke. It is the area most commonly infarcted in people with post-stroke arrhythmias, loss of thermal sensation, hospital acquired pneumonia, and apraxia of speech. We hypothesized that some of these results reflect the fact that: (1) ischemic strokes that involve the insula are larger than strokes that exclude the insula (and therefore are associated with more common and persistent deficits); and (2) insular involvement is a marker of middle cerebral artery (MCA) occlusion. We analyzed MRI scans of 861 patients with acute ischemic hemispheric strokes unselected for functional deficits, and compared infarcts involving the insula to infarcts not involving the insula using t-tests for continuous variables and chi square tests for dichotomous variables. Mean infarct volume was larger for infarcts including the insula (n = 232) versus excluding the insula (n = 629): 65.8 ± 78.8 versus 10.2 ± 15.9 cm3 (p < 0.00001). Even when we removed lacunar infarcts, mean volume of non-lacunar infarcts that included insula (n = 775) were larger than non-lacunar infarcts (n = 227) that excluded insula: 67.0 cm3 ± 79.2 versus 11.5 cm3 ± 16.7 (p < 0.00001). Of infarcts in the 90th percentile for volume, 87% included the insula (χ2 = 181.8; p < 0.00001). Furthermore, 79.0% infarcts due to MCA occlusion included the insula; 78.5% of infarcts without MCA occlusion excluded the insula (χ2 = 93.1; p < 0.0001). The association between insular damage and acute or chronic sequelae likely often reflects the fact that insular infarct is a marker of large infarcts caused by occlusion of the MCA more than a specific role of the insula in a range of functions. Particularly in acute stroke, some deficits may also be due to ischemia of the MCA or ICA territory caused by large vessel occlusion.http://www.sciencedirect.com/science/article/pii/S2213158216300067StrokeInfarct volumeOutcomesInsula |
| spellingShingle | Nishanth Kodumuri Rajani Sebastian Cameron Davis Joseph Posner Eun Hye Kim Donna C. Tippett Amy Wright Argye E. Hillis The association of insular stroke with lesion volume NeuroImage: Clinical Stroke Infarct volume Outcomes Insula |
| title | The association of insular stroke with lesion volume |
| title_full | The association of insular stroke with lesion volume |
| title_fullStr | The association of insular stroke with lesion volume |
| title_full_unstemmed | The association of insular stroke with lesion volume |
| title_short | The association of insular stroke with lesion volume |
| title_sort | association of insular stroke with lesion volume |
| topic | Stroke Infarct volume Outcomes Insula |
| url | http://www.sciencedirect.com/science/article/pii/S2213158216300067 |
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