High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer
Claudin (CLDN) is a tight junction protein found in human epithelial cells and its altered expression is known to be associated with the progression of gastric cancer. We aimed to investigate the differential expression of CLDN-4 in early gastric cancer (EGC) according to its clinicopathological cha...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/11/12/3550 |
| _version_ | 1797485902537162752 |
|---|---|
| author | Won Shik Kim Hayeon Kim Moon Kyung Joo Byung Il Choi Ah Young Yoo Jong-Jae Park Beom Jae Lee Seung Han Kim Hoon Jai Chun |
| author_facet | Won Shik Kim Hayeon Kim Moon Kyung Joo Byung Il Choi Ah Young Yoo Jong-Jae Park Beom Jae Lee Seung Han Kim Hoon Jai Chun |
| author_sort | Won Shik Kim |
| collection | DOAJ |
| description | Claudin (CLDN) is a tight junction protein found in human epithelial cells and its altered expression is known to be associated with the progression of gastric cancer. We aimed to investigate the differential expression of CLDN-4 in early gastric cancer (EGC) according to its clinicopathological characteristics. We enrolled 53 patients with EGC who underwent surgical gastric resection from January 2007 to December 2018. The staining intensity of the tumor cells was scored as 0–3, and the percentage of staining was scored as 0–5; high expression was defined if the intensity plus percentage score was 7 or 8, and low expression was defined if the score was 0–6. Among the 53 patients, 16 (30.2%) showed low CLDN-4 expression, while 37 (69.8%) had high CLDN-4 expression. High CLDN-4 expression was significantly associated with intestinal-type EGC (low: 12.5% vs. high: 56.8%, <i>p</i> = 0.003), open-type atrophic change (low: 60.0% vs. high: 90.9%, <i>p</i> = 0.011), and the presence of synchronous tumors (0 vs. 32.4%, <i>p</i> = 0.010), and all 12 EGCs with synchronous tumors showed high CLDN-4 expression. However, expression of CLDN-3, a typical intestinal phenotype CLDN, was neither correlated with CLDN-4 expression nor associated with synchronous tumors. Taken together, high CLDN-4 expression may be considered as an auxiliary tool for screening synchronous tumors in patients with EGC. |
| first_indexed | 2024-03-09T23:26:27Z |
| format | Article |
| id | doaj.art-7b08393c8b14451d84af8fa37d10a077 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:26:27Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-7b08393c8b14451d84af8fa37d10a0772023-11-23T17:17:48ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011112355010.3390/jcm11123550High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric CancerWon Shik Kim0Hayeon Kim1Moon Kyung Joo2Byung Il Choi3Ah Young Yoo4Jong-Jae Park5Beom Jae Lee6Seung Han Kim7Hoon Jai Chun8Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDepartment of Pathology, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148, Gurodong-ro, Guro-gu, Seoul 08308, KoreaDivision of Gastroenterology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 73, Inchon-ro, Seongbuk-gu, Seoul 02841, KoreaClaudin (CLDN) is a tight junction protein found in human epithelial cells and its altered expression is known to be associated with the progression of gastric cancer. We aimed to investigate the differential expression of CLDN-4 in early gastric cancer (EGC) according to its clinicopathological characteristics. We enrolled 53 patients with EGC who underwent surgical gastric resection from January 2007 to December 2018. The staining intensity of the tumor cells was scored as 0–3, and the percentage of staining was scored as 0–5; high expression was defined if the intensity plus percentage score was 7 or 8, and low expression was defined if the score was 0–6. Among the 53 patients, 16 (30.2%) showed low CLDN-4 expression, while 37 (69.8%) had high CLDN-4 expression. High CLDN-4 expression was significantly associated with intestinal-type EGC (low: 12.5% vs. high: 56.8%, <i>p</i> = 0.003), open-type atrophic change (low: 60.0% vs. high: 90.9%, <i>p</i> = 0.011), and the presence of synchronous tumors (0 vs. 32.4%, <i>p</i> = 0.010), and all 12 EGCs with synchronous tumors showed high CLDN-4 expression. However, expression of CLDN-3, a typical intestinal phenotype CLDN, was neither correlated with CLDN-4 expression nor associated with synchronous tumors. Taken together, high CLDN-4 expression may be considered as an auxiliary tool for screening synchronous tumors in patients with EGC.https://www.mdpi.com/2077-0383/11/12/3550claudin-4early gastric cancersynchronous neoplasms |
| spellingShingle | Won Shik Kim Hayeon Kim Moon Kyung Joo Byung Il Choi Ah Young Yoo Jong-Jae Park Beom Jae Lee Seung Han Kim Hoon Jai Chun High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer Journal of Clinical Medicine claudin-4 early gastric cancer synchronous neoplasms |
| title | High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer |
| title_full | High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer |
| title_fullStr | High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer |
| title_full_unstemmed | High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer |
| title_short | High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Cancer |
| title_sort | high expression of claudin 4 is associated with synchronous tumors in patients with early gastric cancer |
| topic | claudin-4 early gastric cancer synchronous neoplasms |
| url | https://www.mdpi.com/2077-0383/11/12/3550 |
| work_keys_str_mv | AT wonshikkim highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT hayeonkim highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT moonkyungjoo highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT byungilchoi highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT ahyoungyoo highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT jongjaepark highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT beomjaelee highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT seunghankim highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer AT hoonjaichun highexpressionofclaudin4isassociatedwithsynchronoustumorsinpatientswithearlygastriccancer |