Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study
We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocalbased immuno...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2009-06-01
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| Series: | European Journal of Histochemistry |
| Online Access: | https://www.ejh.it/index.php/ejh/article/view/931 |
| _version_ | 1818662101428731904 |
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| author | C Barbato MT Ciotti |
| author_facet | C Barbato MT Ciotti |
| author_sort | C Barbato |
| collection | DOAJ |
| description | We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocalbased immunofluorescence.We found that neurokinin A and neurokinin B are present in CGNs but absent in astrocytes. while substance P is abundant in astrocytes but absent in CGNs. It is postulated that the different localization of tachykinin neuropeptides in CGNs and astroglial cells has a physiological role in the modulation of excitatory transmission. |
| first_indexed | 2024-12-17T04:55:36Z |
| format | Article |
| id | doaj.art-7b096f751142431abe3b0c88d8efa888 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-17T04:55:36Z |
| publishDate | 2009-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-7b096f751142431abe3b0c88d8efa8882022-12-21T22:02:43ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062009-06-0149110.4081/931654Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical studyC BarbatoMT CiottiWe previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocalbased immunofluorescence.We found that neurokinin A and neurokinin B are present in CGNs but absent in astrocytes. while substance P is abundant in astrocytes but absent in CGNs. It is postulated that the different localization of tachykinin neuropeptides in CGNs and astroglial cells has a physiological role in the modulation of excitatory transmission.https://www.ejh.it/index.php/ejh/article/view/931 |
| spellingShingle | C Barbato MT Ciotti Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study European Journal of Histochemistry |
| title | Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study |
| title_full | Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study |
| title_fullStr | Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study |
| title_full_unstemmed | Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study |
| title_short | Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study |
| title_sort | tachykinin neuropeptides in cerebellar granule neurons an immunocytochemical study |
| url | https://www.ejh.it/index.php/ejh/article/view/931 |
| work_keys_str_mv | AT cbarbato tachykininneuropeptidesincerebellargranuleneuronsanimmunocytochemicalstudy AT mtciotti tachykininneuropeptidesincerebellargranuleneuronsanimmunocytochemicalstudy |