Osteosarcopenia: Clinical Perspective
Osteosarcopenia is a geriatric syndrome characterised by the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. This syndrome may lead to falls and fractures, increased morbidity, mortality and disability, and reduced quality of life. The etio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2020-08-01
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| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/osteosarcopenia-clinical-perspective/40097
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| _version_ | 1797919170724102144 |
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| author | Yeşim Gökçe Kutsal Oya Özdemir Merih Sarıdoğan Zafer Günendi Ayşe Küçükdeveci Yeşim Kirazlı Jale Meray |
| author_facet | Yeşim Gökçe Kutsal Oya Özdemir Merih Sarıdoğan Zafer Günendi Ayşe Küçükdeveci Yeşim Kirazlı Jale Meray |
| author_sort | Yeşim Gökçe Kutsal |
| collection | DOAJ |
| description | Osteosarcopenia is a geriatric syndrome characterised by the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. This syndrome may lead to falls and fractures, increased morbidity, mortality and disability, and reduced quality of life. The etiopathogenesis of osteosarcopenia is multifactorial; mechanical, biochemical, genetic and lifestyle factors all play important roles. Its prevalence has been reported between 5% and 37%. The varied prevalence is likely due to the heterogeneous populations or non-unified diagnostic criteria for this syndrome. Osteosarcopenia can be diagnosed by detailed clinical assessment (e.g. screening and risk calculation tools, grip strength, physical performance tests), laboratory tests and imaging methods. Dual-energy X-ray absorptiometry is the most common method used in measuring bone mineral density for the diagnosis of osteoporosis. The imaging techniques used to detect loss of skeletal muscle mass in sarcopenia are dual-energy X-ray absorptiometry, computed tomography, ultrasonography and magnetic resonance imaging. Treatment options for osteosarcopenia include exercise, nutritional supplements (protein, vitamin D, calcium and creatine), life style modifications and pharmacological therapy. With increasing understanding of the underlying mechanisms of osteosarcopenia, the development of therapeutic agents targeting both muscle and bone has become a new area of investigation. This review summarises the epidemiology, pathophysiology, diagnosis and treatment of osteosarcopenia in the light of the relevant literature. |
| first_indexed | 2024-04-10T13:41:19Z |
| format | Article |
| id | doaj.art-7b0c6765e19448f2955bd5dec2bab5f5 |
| institution | Directory Open Access Journal |
| issn | 2147-2653 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T13:41:19Z |
| publishDate | 2020-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-7b0c6765e19448f2955bd5dec2bab5f52023-02-15T16:11:10ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532147-26532020-08-01262475710.4274/tod.galenos.2020.6547713049054Osteosarcopenia: Clinical PerspectiveYeşim Gökçe Kutsal0Oya Özdemir1Merih Sarıdoğan2Zafer Günendi3Ayşe Küçükdeveci4Yeşim Kirazlı5Jale Meray6 Hacettepe Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye Hacettepe Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye İstanbul Üniversitesi-Cerrahpaşa, Cerrahpaşa Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, İstanbul, Türkiye Gazi Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye Ankara Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye Ege Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye Gazi Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye Osteosarcopenia is a geriatric syndrome characterised by the co-existence of osteoporosis and sarcopenia, two chronic musculoskeletal conditions associated with ageing. This syndrome may lead to falls and fractures, increased morbidity, mortality and disability, and reduced quality of life. The etiopathogenesis of osteosarcopenia is multifactorial; mechanical, biochemical, genetic and lifestyle factors all play important roles. Its prevalence has been reported between 5% and 37%. The varied prevalence is likely due to the heterogeneous populations or non-unified diagnostic criteria for this syndrome. Osteosarcopenia can be diagnosed by detailed clinical assessment (e.g. screening and risk calculation tools, grip strength, physical performance tests), laboratory tests and imaging methods. Dual-energy X-ray absorptiometry is the most common method used in measuring bone mineral density for the diagnosis of osteoporosis. The imaging techniques used to detect loss of skeletal muscle mass in sarcopenia are dual-energy X-ray absorptiometry, computed tomography, ultrasonography and magnetic resonance imaging. Treatment options for osteosarcopenia include exercise, nutritional supplements (protein, vitamin D, calcium and creatine), life style modifications and pharmacological therapy. With increasing understanding of the underlying mechanisms of osteosarcopenia, the development of therapeutic agents targeting both muscle and bone has become a new area of investigation. This review summarises the epidemiology, pathophysiology, diagnosis and treatment of osteosarcopenia in the light of the relevant literature. http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/osteosarcopenia-clinical-perspective/40097 osteoporosissarcopeniabone mineral densitymuscle strengthphysical performanceageing |
| spellingShingle | Yeşim Gökçe Kutsal Oya Özdemir Merih Sarıdoğan Zafer Günendi Ayşe Küçükdeveci Yeşim Kirazlı Jale Meray Osteosarcopenia: Clinical Perspective Türk Osteoporoz Dergisi osteoporosis sarcopenia bone mineral density muscle strength physical performance ageing |
| title | Osteosarcopenia: Clinical Perspective |
| title_full | Osteosarcopenia: Clinical Perspective |
| title_fullStr | Osteosarcopenia: Clinical Perspective |
| title_full_unstemmed | Osteosarcopenia: Clinical Perspective |
| title_short | Osteosarcopenia: Clinical Perspective |
| title_sort | osteosarcopenia clinical perspective |
| topic | osteoporosis sarcopenia bone mineral density muscle strength physical performance ageing |
| url |
http://www.turkosteoporozdergisi.org/archives/archive-detail/article-preview/osteosarcopenia-clinical-perspective/40097
|
| work_keys_str_mv | AT yesimgokcekutsal osteosarcopeniaclinicalperspective AT oyaozdemir osteosarcopeniaclinicalperspective AT merihsarıdogan osteosarcopeniaclinicalperspective AT zafergunendi osteosarcopeniaclinicalperspective AT aysekucukdeveci osteosarcopeniaclinicalperspective AT yesimkirazlı osteosarcopeniaclinicalperspective AT jalemeray osteosarcopeniaclinicalperspective |